AIDS and Behavior

, Volume 17, Issue 1, pp 113–121

Medication Persistence of HIV-infected Drug Users on Directly Administered Antiretroviral Therapy


  • Eileen C. Ing
    • Butler Hospital/Alpert Medical School of Brown University
  • Jason W. Bae
    • Section of Infectious DiseasesYale University School of Medicine
  • Duncan Smith-Rohrberg Maru
    • Section of Infectious DiseasesYale University School of Medicine
    • Department of MedicineBrigham and Women’s Hospital
    • Department of MedicineChildren’s Hospital of Boston
    • Section of Infectious Diseases, Department of MedicineYale University School of Medicine
    • Division of Epidemiology of Microbial DiseasesYale School of Public Health
Original Paper

DOI: 10.1007/s10461-011-0082-0

Cite this article as:
Ing, E.C., Bae, J.W., Maru, D.S. et al. AIDS Behav (2013) 17: 113. doi:10.1007/s10461-011-0082-0


Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of ≥ 3 days (AOR: 17.4, P = 0.02) and ≥ 7 days AOR: 5.4, P = 0.04). High addiction severity (AOR 3.2, P = 0.03) was correlated with non-persistence ≥ 7 days, and injection drug use (AOR: 15.2, P = 0.02) with recurrence of non-persistence ≥ 3 days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P = 0.03). There was no significant association between patterns of patient non-persistence and virological outcomes.


HIVAdherencePersistenceDirectly administered antiretroviral therapySubstance abuseDepressionAddiction severity

Copyright information

© Springer Science+Business Media, LLC 2011