Report

AIDS and Behavior

, Volume 14, Issue 5, pp 1066-1071

First online:

Predicting Pregnancy in HIV-1-Discordant Couples

  • Brandon L. GuthrieAffiliated withDepartment of Epidemiology, University of Washington Email author 
  • , Robert Y. ChoiAffiliated withDepartment of Medicine, University of Washington
  • , Rose BosireAffiliated withCentre for Public Health Research, Kenya Medical Research Institute
  • , James N. KiarieAffiliated withDepartment of Obstetrics and Gynaecology, University of Nairobi
  • , Romel D. MackelprangAffiliated withDepartment of Epidemiology, University of Washington
  • , Anne GatugutaAffiliated withDepartment of Community Health, University of Nairobi
  • , Grace C. John-StewartAffiliated withDepartment of Epidemiology, University of WashingtonDepartment of Medicine, University of WashingtonDepartment of Global Health, University of Washington
  • , Carey FarquharAffiliated withDepartment of Epidemiology, University of WashingtonDepartment of Medicine, University of Washington

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.

Keywords

HIV Discordant couples Serodiscordant Pregnancy Predictors Risk factor