Original Paper

AIDS and Behavior

, Volume 13, Issue 6, pp 1037-1045

Open Access This content is freely available online to anyone, anywhere at any time.

Strategies Used in the Detection of Acute/Early HIV Infections. The NIMH Multisite Acute HIV Infection Study: I

  • Peter R. KerndtAffiliated withLos Angeles County Department of Public Health, Sexually Trasmitted Disease Program Email author 
  • , Robert DubrowAffiliated withCenter for Interdisciplinary Research on AIDS, Yale University
  • , Getahun AynalemAffiliated withLos Angeles County Department of Public Health, Sexually Trasmitted Disease Program
  • , Kenneth H. MayerAffiliated withBrown University
  • , Curt BeckwithAffiliated withBrown University
  • , Robert H. RemienAffiliated withHIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, Columbia University
  • , Hong-Ha M. TruongAffiliated withCenter for AIDS Prevention Studies, University of California
  • , Apurva UniyalAffiliated withLos Angeles County Department of Public Health, Sexually Trasmitted Disease Program
  • , Michael ChienAffiliated withLos Angeles County Department of Public Health, Sexually Trasmitted Disease Program
    • , Ronald A. BrooksAffiliated withCenter for HIV Identification, Prevention and Treatment Services, University of California
    • , Ofilio R. VigilAffiliated withHIV Neurobehavioral Research Center, University of California
    • , Wayne T. StewardAffiliated withCenter for AIDS Prevention Studies, University of California
    • , Michael MersonAffiliated withDuke University
    • , Mary Jane Rotheram-BorusAffiliated withCenter for HIV Identification, Prevention and Treatment Services, University of California
    • , Stephen F. MorinAffiliated withCenter for AIDS Prevention Studies, University of California

Abstract

Acute/early HIV infection plays a critical role in onward HIV transmission. Detection of HIV infections during this period provides an important early opportunity to offer interventions which may prevent further transmission. In six US cities, persons with acute/early HIV infection were identified using either HIV RNA testing of pooled sera from persons screened HIV antibody negative or through clinical referral of persons with acute or early infections. Fifty-one cases were identified and 34 (68%) were enrolled into the study; 28 (82%) were acute infections and 6 (18%) were early infections. Of those enrolled, 13 (38%) were identified through HIV pooled testing of 7,633 HIV antibody negative sera and 21 (62%) through referral. Both strategies identified cases that would have been missed under current HIV testing and counseling protocols. Efforts to identify newly infected persons should target specific populations and geographic areas based on knowledge of the local epidemiology of incident infections.

Keywords

Acute HIV infection Nucleic acid amplification tests HIV RNA testing Early detection of acute HIV infection