AIDS and Behavior

, Volume 14, Issue 4, pp 731–747

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

  • Monica Malta
  • Monica M. F. Magnanini
  • Steffanie A. Strathdee
  • Francisco I. Bastos
Original Paper

DOI: 10.1007/s10461-008-9489-7

Cite this article as:
Malta, M., Magnanini, M.M.F., Strathdee, S.A. et al. AIDS Behav (2010) 14: 731. doi:10.1007/s10461-008-9489-7


We conducted a meta-analysis of studies assessing adherence to highly active antiretroviral therapy (HAART) and a qualitative systematic review of factors associated with better HAART outcomes among HIV+ drug users (DU). Thirty-eight studies were considered, which analyzed 14,960 patients (11,394 HIV+ DU, 76.2%). Overall adherence (pooled percent of DU classified as adherent in each study) was 0.60 (95% CI: 0.52–0.68), similar to levels identified by studies conducted with HIV+ patients who are not drug users. Time frame used to measure adherence was an independent predictor of inter-study heterogeneity. The systematic review identified better HAART outcomes among former DU, those with less severe psychiatric conditions, those receiving opioid substitution therapy and/or psychosocial support. Patients initiating HAART with lower viral load and higher CD4 counts, and those without co-infections also had better treatment outcomes. Our findings suggest that HIV+ DU tend to be inappropriately assumed to be less adherent and unlikely to achieve desirable treatment outcomes, when compared to their non-DU cohort.


HIVAIDSAdherenceDrug useMeta-analysis

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Monica Malta
    • 1
  • Monica M. F. Magnanini
    • 2
  • Steffanie A. Strathdee
    • 3
  • Francisco I. Bastos
    • 4
  1. 1.Social Science Department, Sergio Arouca School of Public Health (DCS/ENSP)Oswaldo Cruz FoundationRio de JaneiroBrazil
  2. 2.Institute of Public Health StudiesFederal University of Rio de Janeiro (IESC/UFRJ)Rio de JaneiroBrazil
  3. 3.Division of International Health and Cross Cultural Medicine, Department of Family and Preventive Medicine at University of CaliforniaSan Diego (UCSD) School of MedicineSan DiegoUSA
  4. 4.Health Information Laboratory, Center for Scientific and Technological Information (LIS/ICICT)Oswaldo Cruz FoundationRio de JaneiroBrazil