Original Paper

AIDS and Behavior

, Volume 11, Issue 4, pp 603-610

First online:

The Impact of Chronic Hepatitis C on Health-Related Quality of Life in Homeless and Marginally Housed Individuals with HIV

  • Judith I. TsuiAffiliated withSan Francisco Veterans Administration Medical Center, University of California San Francisco Email author 
  • , David R. BangsbergAffiliated withEpidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San FranciscoPositive Health Program, San Francisco General Hospital
  • , Kathleen RaglandAffiliated withEpidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San Francisco
  • , Christopher S. HallAffiliated withPositive Health Program, San Francisco General HospitalSTD Control Branch, California Department of Health Services, California STD/HIV Prevention Training Center
  • , Elise D. RileyAffiliated withEpidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San Francisco

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Abstract

Although infection with Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) frequently co-exist, there has been little research to determine the effects of HIV/HCV co-infection on health-related quality of life (HRQOL). We performed a cross-sectional analysis of baseline data from 216 participants enrolled in a community based study of HIV-infected homeless and marginally housed individuals, using multivariable linear regression analysis to determine if co-infection with HCV was independently associated with lower short-form 36 (SF-36) questionnaire scores. We found that individuals with HCV had significantly lower mean SF-36 scores in the domains of physical functioning, bodily pain, social functioning and role limitation due to emotional health, and that HIV/HCV co-infection was independently associated with a lower physical component score but not a lower mental component score after controlling for numerous covariates. These results suggest that co-infection with HCV may have an adverse effect on HRQOL among homeless and marginally housed individuals with HIV.

Keywords

Hepatitis C HIV Quality of Life Homelessness