AIDS and Behavior

, Volume 11, Issue 4, pp 603–610

The Impact of Chronic Hepatitis C on Health-Related Quality of Life in Homeless and Marginally Housed Individuals with HIV

Authors

    • San Francisco Veterans Administration Medical CenterUniversity of California San Francisco
  • David R. Bangsberg
    • Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General HospitalUniversity of California San Francisco
    • Positive Health ProgramSan Francisco General Hospital
  • Kathleen Ragland
    • Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General HospitalUniversity of California San Francisco
  • Christopher S. Hall
    • Positive Health ProgramSan Francisco General Hospital
    • STD Control Branch, California Department of Health ServicesCalifornia STD/HIV Prevention Training Center
  • Elise D. Riley
    • Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General HospitalUniversity of California San Francisco
Original Paper

DOI: 10.1007/s10461-006-9157-8

Cite this article as:
Tsui, J.I., Bangsberg, D.R., Ragland, K. et al. AIDS Behav (2007) 11: 603. doi:10.1007/s10461-006-9157-8

Abstract

Although infection with Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) frequently co-exist, there has been little research to determine the effects of HIV/HCV co-infection on health-related quality of life (HRQOL). We performed a cross-sectional analysis of baseline data from 216 participants enrolled in a community based study of HIV-infected homeless and marginally housed individuals, using multivariable linear regression analysis to determine if co-infection with HCV was independently associated with lower short-form 36 (SF-36) questionnaire scores. We found that individuals with HCV had significantly lower mean SF-36 scores in the domains of physical functioning, bodily pain, social functioning and role limitation due to emotional health, and that HIV/HCV co-infection was independently associated with a lower physical component score but not a lower mental component score after controlling for numerous covariates. These results suggest that co-infection with HCV may have an adverse effect on HRQOL among homeless and marginally housed individuals with HIV.

Keywords

Hepatitis CHIVQuality of LifeHomelessness

Abbreviations

HCV

Hepatitis C virus

HRQOL

Health-related quality of life

HIV

Human immunodeficiency virus

SF-36

Short form 36

PCS

Physical component scale

MCS

Mental component scale

HAART

Highly active anti-retroviral therapy

HMH

Homeless/marginally housed

Copyright information

© Springer Science+Business Media, Inc. 2006