AIDS and Behavior

, 10:185

Additive Deleterious Effects of Methamphetamine Dependence and Immunosuppression on Neuropsychological Functioning in HIV Infection

  • Catherine L. Carey
  • Steven Paul Woods
  • Julie D. Rippeth
  • Raul Gonzalez
  • Robert K. Heaton
  • Igor Grant
  • The HIV Neurobehavioral Research Center (HNRC) Group
Other Research Articles

DOI: 10.1007/s10461-005-9056-4

Cite this article as:
Carey, C.L., Woods, S.P., Rippeth, J.D. et al. AIDS Behav (2006) 10: 185. doi:10.1007/s10461-005-9056-4

Methamphetamine (MA) dependence and HIV infection are independently associated with cerebral dysfunction, especially within frontal-basal ganglia circuits. Recent evidence indicates that MA dependence has an additive effect on neuropsychological (NP) deficits associated with HIV infection. This study extends prior findings by examining the combined effects of MA dependence (MA+) and immunosuppression (i.e., CD4 lymphocyte count <200) on NP functioning in 284 HIV+ individuals. Prevalence of NP impairment was examined in four demographically comparable groups: (1) MA+/CD4 < 200; (2) MA+/CD4 ≥ 200; (3) MA−/CD4 < 200; and (4) MA−/CD4 ≥ 200. Results revealed that both MA dependence and immunosuppression were significant predictors of NP impairment. More importantly, additive effects were evident whereby the MA+/CD4 < 200 group exhibited the highest rate of NP impairment. Findings indicate that MA dependence conveys an additive deleterious impact on NP status in immunosuppressed persons with HIV infection, perhaps reflecting the combined effects of neuropathophysiological mechanisms in fronto-striatal circuits.

KEY WORDS:

human immunodeficiency virus methamphetamine neuropsychology 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Catherine L. Carey
    • 1
  • Steven Paul Woods
    • 2
    • 3
  • Julie D. Rippeth
    • 2
  • Raul Gonzalez
    • 1
  • Robert K. Heaton
    • 1
  • Igor Grant
    • 1
  • The HIV Neurobehavioral Research Center (HNRC) Group
  1. 1.Joint Doctoral Program in Clinical PsychologySan Diego State University and University of CaliforniaSan DiegoUSA
  2. 2.Department of PsychiatryUniversity of CaliforniaSan DiegoUSA
  3. 3.Psy.D., HIV Neurobehavioural Research Center, Department of PsychiatryUniversity of CaliforniaSan DiegoUSA