Variations in Patterns of Highly Active Antiretroviral Therapy (HAART) Adherence
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Strict adherence to highly active antiretroviral therapy (HAART) is necessary for successful suppression of HIV replication. A large number of individuals are not adherent, however, and the reasons for non-adherence are varied and complex. We utilized cluster analyses to identify subgroups of adherers in a sample of 222 HIV positive individuals whose HAART use was electronically monitored. Five distinct subgroups were identified, with characteristic variations across the week and over the course of the 4-week study. Additional comparisons of demographic and behavioral variables found the worst adherers to have higher rates of substance use, and that a group with higher rates of cognitive impairment had a consistent drop in adherence during the weekends. In addition, the group with the best adherence had more individuals over the age of 50 years. The results of the current study indicate that distinct subgroups of adherers may exist, and suggest that interventions designed to improve adherence can be designed to accommodate this variability in behavior.
- Ammassari, A., Trotta, M., Murri, R., Castelli, F., Narciso, P., Noto, P., Vecchiet, J., Monforte, A. D., Wu, A. W., and Antinori, A. (2002). Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature. Journal of Acquired Immune Deficiency Syndromes, 31, S123–S127.
- Bangsberg, D., Hecht, F., Charlebois, E., Zolopa, A., Holodniy, M., Sheiner, L., Bamberger, J. D., Chesney, M. A., and Moss, A. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS, 14, 357–366. CrossRef
- Carrieri, P., Cailleton, V., Le Moing, V., Spire, B., Dellamonica, P., Bouvet, E., Raffi, F., Journot, V., Moatti, J.-P., and the APROCO Study Group. (2001). The dynamic of adherence to highly active antiretroviral therapy: Results from the French National APROCO Cohort. Journal of Acquired Immune Deficiency Syndromes, 28, 232–239.
- Cook, R., Sereika, S., Hunt, S., Woodward, W., Erlen, J., and Conigliaro, J. (2001). Problem drinking and medication adherence among persons with HIV infection. Journal of General Internal Medicine, 16, 137–139. CrossRef
- Everitt, B. (1993). Cluster analysis. New York: Wiley.
- Fogarty, L., Roter, D., Larson, S., Burke, J., Gillespie, J., and Levy, R. (2002). Patient adherence to HIV medication regimens: a review of published and abstract reports. Patient Education and Counseling, 46, 93–108. CrossRef
- Golin, C., Liu, H., Hays, R., Miller, L., Beck, K., Ickovics, J., Kaplan, A. H., and Wenger, N. S. (2002). A prospective study of predictors of adherence to combination antiretroviral medication. Journal of General Internal Medicine, 17, 756–765. CrossRef
- Grober, E., and Sliwinski, M. (1991). Development and validation of a model for estimating premorbid verbal intelligence in the elderly. Journal of Clinical and Experimental Neuropsychology, 13, 933–949. CrossRef
- Heaton, R., Grant, I., and Matthews, C. (1991). Comprehensive norms for an expanded Halstead-Reitan battery: Demographic corrections, research findings, and clinical implications. Odessa, FL: Psychological Assessment Resources.
- Hinkin, C., Castellon, S., Durvasula, R., Hardy, D., Lam, M., Mason, K. I., Thrasher, D., Goetz, M. B., and Stefaniak, M. (2002). Medication adherence among HIV positive adults. Neurology, 59, 1944–1950.
- Hinkin, C.H., Hardy, D., Mason, K., Castellon, S., Durvasula, R., Lam, M., and Stefaniak, M. (2004). Medication adherence in HIV-infected adults: effects of patient age, cognitive status, and substance abuse. AIDS, 18(Suppl 1), S19–S25.
- Howard, A., Arnsten, J., Lo, Y., Vlohav, D., Rich, J., Schuman, P., Stone, V. E., Smith, D. K., and Schoenbaum, E. E. (2002). A prospective study of adherence and viral load in a large multi-center cohort of HIV-infected women. AIDS, 16, 2175–2182. CrossRef
- Liu, H., Golin, C., Miller, L., Hays, R., Beck, K., Sanandaji, S., Christian, J., Maldonado, T., Duran, D., Kaplan, A. H., and Wenger, N. S. (2001). A comparison study of multiple measures of adherence to HIV protease inhibitors. Annals of Internal Medicine, 134, 968–977.
- Spitzer, R., Williams, J., Gibbon, M., and First, M. (1992). Structured clinical interview for DSM-III-R (SCID). I: History, rationale, and description. Archives of General Psychiatry, 49, 624–629.
- Wijngaerden, E., De Saar, V., De Graeve, V., Vandamme, A. M., Van Vaerenbergh, K., Bobbaers, H., Deschamps, A., Ceunen, H., and De Geest, S. (2002). Nonadherence to highly active antiretroviral therapy: Clinically relevant patient categorization based on electronic event monitoring. AIDS Research and Human Retroviruses, 18, 327–330. CrossRef
- Wilson, I., Tchetgen, E., and Spiegelman, D. (2001). Patterns of adherence with antiretroviral medications: An examination of between-medication differences. Journal of Acquired Immune Deficiency Syndromes, 28, 259–263.
- Variations in Patterns of Highly Active Antiretroviral Therapy (HAART) Adherence
AIDS and Behavior
Volume 9, Issue 3 , pp 355-362
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- antiretroviral therapy
- substance abuse
- Industry Sectors
- Author Affiliations
- 1. Neuropsychiatric Institute, University of California, Los Angeles, California, USA
- 5. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Room C8-747, Los Angeles, 90024-1759, California, USA
- 2. Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA
- 4. Department of Psychology, University of California, Los Angeles, California, USA
- 3. California State University, Los Angeles, California, USA