Angiogenesis

, Volume 8, Issue 2, pp 127–136

Sex steroid regulation of angiogenesis in breast tissue

  • Charlotta Dabrosin
Review

DOI: 10.1007/s10456-005-9002-0

Cite this article as:
Dabrosin, C. Angiogenesis (2005) 8: 127. doi:10.1007/s10456-005-9002-0

Abstract

Angiogenesis is essential for normal function in the female reproductive tract and a prerequisite for growth and metastasis of solid tumors. Several factors, both inducers and inhibitors, play essential roles in the regulation of the angiogenic process. Exposure to sex steroids increases the risk of breast cancer but the mechanisms are poorly understood and the importance of angiogenesis in breast carcinogenesis is undefined. In the female reproductive tract ovarian hormones tightly regulate angiogenesis. The breast is also a target organ for sex steroids but very little is known about sex steroid effects on angiogenesis in normal breast tissue and breast cancer. In this review several regulators of angiogenesis, and their relation to sex steroids, in breast tissue are discussed. Increased knowledge in this area is of utmost importance for future therapeutic treatment options and for breast cancer prevention.

Keywords

cancerestrogenmammaryprogesteronetamoxifen

Abbreviations

Ang

angiopoietin

bFGF

basic fibroblast growth factor

EGFR

epidermal growth factor receptor

ER

estrogen receptor

IGF-1

insulin like growth factor-1

IL-1

interleukin 1

IL-8

interleukin-8

IP-10

interferon inducible protein-10

MMP

matrix metalloproteinase

PAF

platelet activating factor

sVEGFR-1

soluble vascular endothelial growth factor receptor-1

TGF

transforming growth factor

TSP-1

thrombospondin-1

VEGF

vascular endothelial growth factor

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Charlotta Dabrosin
    • 1
  1. 1.Division of Gynecologic OncologyUniversity Hospital, Faculty of Health SciencesLinköpingSweden