Acta Biotheoretica

, Volume 53, Issue 3, pp 181–190

Correlating Velocity Patterns With Spatial Dynamics In Glioma Cell Migration


DOI: 10.1007/s10441-005-2527-1

Cite this article as:
Deisboeck, T.S., Demuth, T. & Mansury, Y. Acta Biotheor (2005) 53: 181. doi:10.1007/s10441-005-2527-1


Highly malignant neuroepithelial tumors are known for their extensive tissue invasion. Investigating the relationship between their spatial behavior and temporal patterns by employing detrended fluctuation analysis (DFA), we report here that faster glioma cell motility is accompanied by both greater predictability of the cells' migration velocity and concomitantly, more directionality in the cells' migration paths. Implications of this finding for both experimental and clinical cancer research are discussed.

Key Words

Glioma cell migrationDetrended fluctuations analysis

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Thomas S. Deisboeck
    • 1
    • 2
    • 4
  • Tim Demuth
    • 3
  • Yuri Mansury
    • 1
    • 2
  1. 1.Complex Biosystems Modeling Laboratory, HST-Biomedical Engineering CenterMassachusetts Institute of TechnologyCambridge
  2. 2.Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalMassachusetts General HospitalCharlestown
  3. 3.Neurogenomics DivisionTranslational Genomics Research InstitutePhoenix
  4. 4.Complex Biosystems Modeling Laboratory, Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General Hospital-EastCharlestown