Correlating Velocity Patterns With Spatial Dynamics In Glioma Cell Migration
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Highly malignant neuroepithelial tumors are known for their extensive tissue invasion. Investigating the relationship between their spatial behavior and temporal patterns by employing detrended fluctuation analysis (DFA), we report here that faster glioma cell motility is accompanied by both greater predictability of the cells' migration velocity and concomitantly, more directionality in the cells' migration paths. Implications of this finding for both experimental and clinical cancer research are discussed.
- Buldyrev, S.V., A.L. Goldberger, S. Havlin, R.N. Mantegna, M.E. Matsa, C.K. Peng, M. Simons and H.E. Stanley (1995). Long-range correlation properties of coding and noncoding DNA sequences: GenBank analysis. Phys Rev E 51: 5084–5091. CrossRef
- CBTRUS (2002). Statistical Report: Primary Brain Tumors in the United States, 1995–1999. The Central Brain Tumor Registry of the United States (http://www.cbtrus.org).
- Chicoine, M.R. and D.L. Silbergeld (1995). The in vitro motility of human gliomas increases with increasing grade of malignancy. Cancer 75: 2904–2909.
- Demuth, T., N.J. Hopf, O. Kempski, D. Sauner, M. Herr, A. Giese and A. Perneczky. (2001). Migratory activity of human glioma cell lines in vitro assessed by continuous single cell observation. Clin Exp Metastasis 18: 589–597.
- Ekstrand, A.J., C.D. James, W.K. Cavenee, B. Seliger, R.F. Pettersson and V.P. Collins (1991). Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 51: 2164–2172.
- Hegedus, B., A. Czirok, I. Fazekas, T. Babel, E. Madarasz and T. Vicsek. (2000). Locomotion and proliferation of glioblastoma cells in vitro: statistical evaluation of videomicroscopic observations. J Neurosurg 92: 428–434.
- Lund-Johansen, M., R. Bjerkvig, P.A. Humphrey, S.H. Bigner, D.D. Bigner and O.D. Laerum (1990). Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. Cancer Res. 50: 6039–6044.
- Mansury, Y. and T.S. Deisboeck (2004). Simulating the time series of a selected gene expression profile in an agent-based tumor model. Physica D 196: 193–204.
- Nazzaro, J.M. and E.A. Neuwelt (1990). The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults. J Neurosurg. 73: 331–344.
- Okada, Y., E.E. Hurwitz, J.M. Esposito, M.A. Brower, C.L. Nutt and D.N. Louis. (2003). Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas. Cancer Res. 63: 413–416.
- Peng, C.K., S.V. Buldyrev, A.L. Goldberger, S. Havlin, M. Simons and H.E. Stanley. (1993). Finite-size effects on long-range correlations: Implications for analyzing DNA sequences. Phys Rev E 47: 3730–3733. CrossRef
- Peng, C.K., S.V. Buldyrev, S. Havlin, M. Simons, H.E. Stanley and A.L. Goldberger. (1994). Mosaic organization of DNA nucleotides. Phys Rev E 49: 1685–1689. CrossRef
- Silbergeld, D.L. and M.R. Chicoine (1997). Isolation and characterization of human malignant glioma cells from histologically normal brain. J Neurosurg. 86: 525–531.
- Stanley, H.E., L.A.N. Amaral, A.L. Goldberger, S. Havlin, P.C. Ivanov and C.K. Peng. (1999). Statistical physics and physiology: Monofractal and multifractal approaches. Physica A 270: 309–324. CrossRef
- Correlating Velocity Patterns With Spatial Dynamics In Glioma Cell Migration
Volume 53, Issue 3 , pp 181-190
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Glioma cell migration
- Detrended fluctuations analysis
- Author Affiliations
- 1. Complex Biosystems Modeling Laboratory, HST-Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, MA, 02139
- 2. Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Massachusetts General Hospital, Charlestown, MA, 02129
- 4. Complex Biosystems Modeling Laboratory, Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital-East, 2301, Bldg. 149, 13th Street, Charlestown, MA, 02129
- 3. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004