Annals of Biomedical Engineering

, Volume 43, Issue 3, pp 657–680

Clinical Applications of Naturally Derived Biopolymer-Based Scaffolds for Regenerative Medicine

  • Whitney L. Stoppel
  • Chiara E. Ghezzi
  • Stephanie L. McNamara
  • Lauren D. Black III
  • David L. Kaplan
Article

DOI: 10.1007/s10439-014-1206-2

Cite this article as:
Stoppel, W.L., Ghezzi, C.E., McNamara, S.L. et al. Ann Biomed Eng (2015) 43: 657. doi:10.1007/s10439-014-1206-2

Abstract

Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable mechanical and degradation kinetics. The use of these natural biopolymers in biomedical applications is advantageous because they do not release cytotoxic degradation products, are often processed using environmentally-friendly aqueous-based methods, and their degradation rates within biological systems can be manipulated by modifying the starting formulation or processing conditions. For these reasons, many recent in vivo investigations and FDA-approval of new biomaterials for clinical use have utilized natural biopolymers as matrices for cell delivery and as scaffolds for cell-free support of native tissues. This review highlights biopolymer-based scaffolds used in clinical applications for the regeneration and repair of native tissues, with a focus on bone, skeletal muscle, peripheral nerve, cardiac muscle, and cornea substitutes.

Keywords

Biopolymers Scaffolds Regenerative medicine 

Copyright information

© Biomedical Engineering Society 2014

Authors and Affiliations

  • Whitney L. Stoppel
    • 1
  • Chiara E. Ghezzi
    • 1
  • Stephanie L. McNamara
    • 1
    • 2
    • 3
  • Lauren D. Black III
    • 1
    • 2
  • David L. Kaplan
    • 1
  1. 1.Department of Biomedical EngineeringTufts UniversityMedfordUSA
  2. 2.Cellular, Molecular and Developmental Biology Program, Sackler School of Graduate Biomedical SciencesTufts University School of MedicineBostonUSA
  3. 3.The Harvard/MIT MD-PhD ProgramHarvard Medical SchoolBostonUSA