Annals of Biomedical Engineering

, Volume 43, Issue 3, pp 501–514

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

  • Charles M. Rubert Pérez
  • Nicholas Stephanopoulos
  • Shantanu Sur
  • Sungsoo S. Lee
  • Christina Newcomb
  • Samuel I. Stupp
Article

DOI: 10.1007/s10439-014-1166-6

Cite this article as:
Rubert Pérez, C.M., Stephanopoulos, N., Sur, S. et al. Ann Biomed Eng (2015) 43: 501. doi:10.1007/s10439-014-1166-6

Abstract

In an effort to develop bioactive matrices for regenerative medicine, peptides have been used widely to promote interactions with cells and elicit desired behaviors in vivo. This paper describes strategies that utilize peptide-based molecules as building blocks to create supramolecular nanostructures that emulate not only the architecture but also the chemistry of the extracellular matrix in mammalian biology. After initiating a desired regenerative response in vivo, the innate biodegradability of these systems allow for the natural biological processes to take over in order to promote formation of a new tissue without leaving a trace of the nonnatural components. These bioactive matrices can either bind or mimic growth factors or other protein ligands to elicit a cellular response, promote specific mechano-biological responses, and also guide the migration of cells with programmed directionality. In vivo applications discussed in this review using peptide-based matrices include the regeneration of axons after spinal cord injury, regeneration of bone, and the formation of blood vessels in ischemic muscle as a therapy in peripheral arterial disease and cardiovascular diseases.

Keywords

Regenerative medicine Tissue engineering Biomaterials Self-assembly Bioactive peptides 

Copyright information

© Biomedical Engineering Society 2014

Authors and Affiliations

  • Charles M. Rubert Pérez
    • 1
  • Nicholas Stephanopoulos
    • 1
  • Shantanu Sur
    • 1
    • 3
  • Sungsoo S. Lee
    • 2
  • Christina Newcomb
    • 2
  • Samuel I. Stupp
    • 1
    • 2
  1. 1.Simpson Querrey Institute of BioNanotechnologyNorthwestern UniversityChicagoUSA
  2. 2.Department of Materials and Science & Engineering, Chemistry, Medicine, and Biomedical EngineeringNorthwestern UniversityEvanstonUSA
  3. 3.Department of BiologyClarkson UniversityPotsdamUSA