Annals of Biomedical Engineering

, Volume 41, Issue 6, pp 1233–1242

Resting EEG Discrimination of Early Stage Alzheimer’s Disease from Normal Aging Using Inter-Channel Coherence Network Graphs

  • Joseph McBride
  • Xiaopeng Zhao
  • Nancy Munro
  • Charles Smith
  • Gregory Jicha
  • Yang Jiang
Article

DOI: 10.1007/s10439-013-0788-4

Cite this article as:
McBride, J., Zhao, X., Munro, N. et al. Ann Biomed Eng (2013) 41: 1233. doi:10.1007/s10439-013-0788-4

Abstract

Amnestic mild cognitive impairment (MCI) is a degenerative neurological disorder at the early stage of Alzheimer’s disease (AD). This work is a pilot study aimed at developing a simple scalp-EEG-based method for screening and monitoring MCI and AD. Specifically, the use of graphical analysis of inter-channel coherence of resting EEG for the detection of MCI and AD at early stages is explored. Resting EEG records from 48 age-matched subjects (mean age 75.7 years)—15 normal controls (NC), 16 with early-stage MCI, and 17 with early-stage AD—are examined. Network graphs are constructed using pairwise inter-channel coherence measures for delta–theta, alpha, beta, and gamma band frequencies. Network features are computed and used in a support vector machine model to discriminate among the three groups. Leave-one-out cross-validation discrimination accuracies of 93.6% for MCI vs. NC (p < 0.0003), 93.8% for AD vs. NC (p < 0.0003), and 97.0% for MCI vs. AD (p < 0.0003) are achieved. These results suggest the potential for graphical analysis of resting EEG inter-channel coherence as an efficacious method for noninvasive screening for MCI and early AD.

Keywords

EEG-based diagnosisEarly Alzheimer’s diseaseMild cognitive impairmentCoherenceGraphical analysis

Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Joseph McBride
    • 1
  • Xiaopeng Zhao
    • 1
    • 2
  • Nancy Munro
    • 3
  • Charles Smith
    • 4
    • 6
  • Gregory Jicha
    • 4
    • 6
  • Yang Jiang
    • 5
    • 6
  1. 1.Department of Mechanical, Aerospace, and Biomedical EngineeringUniversity of TennesseeKnoxvilleUSA
  2. 2.National Institute for Mathematical and Biological SynthesisUniversity of TennesseeKnoxvilleUSA
  3. 3.Oak Ridge National LaboratoryOak RidgeUSA
  4. 4.Department of NeurologyUniversity of KentuckyLexingtonUSA
  5. 5.Department of Behavioral ScienceUniversity of KentuckyLexingtonUSA
  6. 6.Sanders-Brown Center on AgingUniversity of KentuckyLexingtonUSA