Annals of Biomedical Engineering

, Volume 41, Issue 4, pp 725–743

Virtual Treatment of Basilar Aneurysms Using Shape Memory Polymer Foam

Authors

    • Engineering Technologies DivisionLawrence Livermore National Laboratory
  • J. Hartman
    • Department of NeurosurgeryKaiser Permanente Medical Center
  • J. N. Rodriguez
    • Department of Biomedical EngineeringTexas A&M University
  • D. J. Maitland
    • Department of Biomedical EngineeringTexas A&M University
Article

DOI: 10.1007/s10439-012-0719-9

Cite this article as:
Ortega, J.M., Hartman, J., Rodriguez, J.N. et al. Ann Biomed Eng (2013) 41: 725. doi:10.1007/s10439-012-0719-9

Abstract

Numerical simulations are performed on patient-specific basilar aneurysms that are treated with shape memory polymer (SMP) foam. In order to assess the post-treatment hemodynamics, two modeling approaches are employed. In the first, the foam geometry is obtained from a micro-CT scan and the pulsatile blood flow within the foam is simulated for both Newtonian and non-Newtonian viscosity models. In the second, the foam is represented as a porous media continuum, which has permeability properties that are determined by computing the pressure gradient through the foam geometry over a range of flow speeds comparable to those of in vivo conditions. Virtual angiography and additional post-processing demonstrate that the SMP foam significantly reduces the blood flow speed within the treated aneurysms, while eliminating the high-frequency velocity fluctuations that are present within the pre-treatment aneurysms. An estimation of the initial locations of thrombus formation throughout the SMP foam is obtained by means of a low fidelity thrombosis model that is based upon the residence time and shear rate of blood. The Newtonian viscosity model and the porous media model capture similar qualitative trends, though both yield a smaller volume of thrombus within the SMP foam.

Keywords

AneurysmShape memory polymer foamComputational fluid dynamicsPost-treatment hemodynamics

Abbreviations

BA

Basilar artery

CFD

Computational fluid dynamics

FHDD

Forchheimer-Hazen-Dupuit-Darcy

GDC

Guglielmi detachable coil

PCA

Posterior cerebral artery

SCA

Superior cerebellar artery

SMP

Shape memory polymer

Supplementary material

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Copyright information

© Biomedical Engineering Society 2013