Annals of Biomedical Engineering

, Volume 40, Issue 4, pp 777–789

The Role of Sugars in Dendritic Cell Trafficking

  • Zélia Silva
  • Konstantinos Konstantopoulos
  • Paula A. Videira
Article

DOI: 10.1007/s10439-011-0448-5

Cite this article as:
Silva, Z., Konstantopoulos, K. & Videira, P.A. Ann Biomed Eng (2012) 40: 777. doi:10.1007/s10439-011-0448-5

Abstract

Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists for DCs with improved migratory capacity upon adoptive transfer into patients. One critical step that directs the trafficking of DCs throughout the body is their egress from the vasculature, starting with their adhesive interactions with vascular endothelium under shear flow. Both tethering and rolling rely on interactions mediated by specific glycans attached to glycoproteins and glycolipids present on the DC surface. In DCs, surface glycosylation, including the expression of selectin ligands, changes significantly depending on the local microenvironment and the functional state of the cells. These changes have been documented and have potential implications in important cell functions such as migration. In this article, we review the glycobiological aspects in the context of DC interaction with endothelium, and offer insights on how it can be applied to modulate DC applicability in therapy.

Keywords

Dendritic cells Migration Selectin Sialyl Lewisx Adhesion Shear flow 

Abbreviations

CCL

C–C-chemokine ligand

CCR

C–C-chemokine receptor

DC

Dendritic cell

DC-SIGN

Dendritic cell-specific intracellular adhesion molecule-3 grabbing non-integrin

Fuc

Fucose

Gal

Galactose

GlcNAc

N-Acetylglucosamine

LN

Lymph nodes

MHC

Major histocompatibility complex

Mo-DC

Monocyte-derived dendritic cell

PGE2

Prostaglandin E2

PSGL-1

P-Selectin glycoprotein ligand-1

Siglec

Sialic acid-binding immunoglobulin-like lectin

sLex

Sialyl Lewis X antigen

Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Zélia Silva
    • 1
  • Konstantinos Konstantopoulos
    • 2
    • 3
  • Paula A. Videira
    • 1
  1. 1.CEDOC, Departamento de Imunologia, Faculdade de Ciências MédicasUniversidade Nova de LisboaLisboaPortugal
  2. 2.Department of Chemical and Biomolecular EngineeringThe Johns Hopkins UniversityBaltimoreUSA
  3. 3.Institute for NanoBioTechnologyThe Johns Hopkins UniversityBaltimoreUSA