Annals of Biomedical Engineering

, 39:2759

Novel Biodegradable Polycaprolactone Occlusion Device Combining Nanofibrous PLGA/Collagen Membrane for Closure of Atrial Septal Defect (ASD)

  • Shih-Jung Liu
  • Kang-Ming Peng
  • Chao-Ying Hsiao
  • Kuo-Sheng Liu
  • Hung-Tao Chung
  • Jan-Kan Chen
Article

DOI: 10.1007/s10439-011-0368-4

Cite this article as:
Liu, SJ., Peng, KM., Hsiao, CY. et al. Ann Biomed Eng (2011) 39: 2759. doi:10.1007/s10439-011-0368-4

Abstract

The purpose of this report was to develop novel biodegradable occlusion devices for closure of atrial septal defects (ASD). To manufacture the biodegradable occluders, polycaprolactone (PCL) components were first fabricated by a lab-scale micro-injection molding machine. They were then assembled and hot-spot welded into double umbrella-like devices of 50 mm in diameter. A special mechanism at the axis of the occluder was designed to self-lock the occluder after the two umbrellas were expanded. Furthermore, a nanofibrous matrix of poly-d-l-lactide-glycolide (PLGA)/type I collagen blend was produced via electrospinning to develop biodegradable and biomimetic anti-shunt membranes for the occluders. Characterization of the biodegradable PCL occluders was carried out. PCL occluders exhibited mechanical properties comparable to that of commercially available Amplatzer occluders. The sealing capability of biodegradable occluders was found superior to that of Amplatzer occluders. In addition, the cell attachment and spreading of endothelial cells seeded on the PLGA/collagen nanofibrous matrix and the interaction between cells and PLGA/collagen nanofibers were studied. The nanofibrous membranes made of PLGA/collagen were very effective in promoting cell proliferation during culture.

Keywords

Biodegradable occlusion devices Polycaprolactone PLGA/collagen nanofibers Mechanical properties Cell behavior 

Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Shih-Jung Liu
    • 1
  • Kang-Ming Peng
    • 1
  • Chao-Ying Hsiao
    • 1
  • Kuo-Sheng Liu
    • 1
    • 2
  • Hung-Tao Chung
    • 3
  • Jan-Kan Chen
    • 4
  1. 1.Biomaterials Lab, Mechanical EngineeringChang Gung UniversityTao-YuanTaiwan
  2. 2.Department of Thoracic and Cardiovascular SurgeryChang Gung Memorial HospitalTao-YuanTaiwan
  3. 3.Division of Pediatric Cardiology, Department of PediatricsChang Gung Memorial HospitalTao-YuanTaiwan
  4. 4.Department of Physiology and PharmacologyChang Gung UniversityTao-YuanTaiwan