Novel Biodegradable Polycaprolactone Occlusion Device Combining Nanofibrous PLGA/Collagen Membrane for Closure of Atrial Septal Defect (ASD)
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The purpose of this report was to develop novel biodegradable occlusion devices for closure of atrial septal defects (ASD). To manufacture the biodegradable occluders, polycaprolactone (PCL) components were first fabricated by a lab-scale micro-injection molding machine. They were then assembled and hot-spot welded into double umbrella-like devices of 50 mm in diameter. A special mechanism at the axis of the occluder was designed to self-lock the occluder after the two umbrellas were expanded. Furthermore, a nanofibrous matrix of poly-d-l-lactide-glycolide (PLGA)/type I collagen blend was produced via electrospinning to develop biodegradable and biomimetic anti-shunt membranes for the occluders. Characterization of the biodegradable PCL occluders was carried out. PCL occluders exhibited mechanical properties comparable to that of commercially available Amplatzer occluders. The sealing capability of biodegradable occluders was found superior to that of Amplatzer occluders. In addition, the cell attachment and spreading of endothelial cells seeded on the PLGA/collagen nanofibrous matrix and the interaction between cells and PLGA/collagen nanofibers were studied. The nanofibrous membranes made of PLGA/collagen were very effective in promoting cell proliferation during culture.
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- Novel Biodegradable Polycaprolactone Occlusion Device Combining Nanofibrous PLGA/Collagen Membrane for Closure of Atrial Septal Defect (ASD)
Annals of Biomedical Engineering
Volume 39, Issue 11 , pp 2759-2766
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Biodegradable occlusion devices
- PLGA/collagen nanofibers
- Mechanical properties
- Cell behavior
- Industry Sectors
- Author Affiliations
- 1. Biomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 333, Taiwan
- 2. Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan
- 3. Division of Pediatric Cardiology, Department of Pediatrics, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan
- 4. Department of Physiology and Pharmacology, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan