MEMS Thermal Sensors to Detect Changes in Heat Transfer in the Pre-Atherosclerotic Regions of Fat-Fed New Zealand White Rabbits
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Real-time detection of pre-atherosclerotic regions remains an unmet clinical challenge. We previously demonstrated the application of micro-electro-mechanical systems (MEMS) to detect changes in convective heat transfer in terms of sensor output voltages in the zone of flow reversal in an in vitro stenotic model. We hereby demonstrated changes in sensor output voltages in the pre-atherosclerotic regions in the New Zealand White rabbits fed on hypercholesterolemic diet (HD). After 8 weeks, we observed that mean output voltages (V ave) were similar in the distal aortic arch, thoracic, and abdominal aortas in the normal standard diet (ND) group, consistent with an absence of atherosclerosis. In HD group, V ave increased in the distal aortic arch (HD: V ave = 1.05 ± 0.04 V; ND: V ave = 0.12 ± 0.01 V, n = 3, p < 0.05) and in the thoracic aortas (HD: V ave = 0.72 ± 0.06 V; ND: V ave = 0.13 ± 0.024 V, n = 3, p < 0.05), consistent with the histological presence of pre-atherosclerosis. Despite HD diet, V ave magnitudes were similar to ND group in the abdominal aortas (HD: V ave = 0.14 ± 0.003 V; ND: V ave = 0.14 ± 0.004 V, n = 3), corroborating histological absence of pre-atherosclerosis. Hence, MEMS thermal sensors provide a new approach to detect changes in convective heat transfer in the pre-atherosclerotic regions.
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- MEMS Thermal Sensors to Detect Changes in Heat Transfer in the Pre-Atherosclerotic Regions of Fat-Fed New Zealand White Rabbits
Annals of Biomedical Engineering
Volume 39, Issue 6 , pp 1736-1744
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- Springer US
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- Heat transfer
- Disturbed flow
- Shear stress
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- Author Affiliations
- 1. Department of Biomedical Engineering and Division of Cardiovascular Medicine, School of Engineering & School of Medicine, University of Southern California, Los Angeles, CA, 90089-1111, USA
- 2. The Heart Institute, Good Samaritan Hospital, Los Angeles, CA, 90017, USA
- 3. Department of Pathology, UCLA David Geffen School of Medicine, Los Angeles, CA, 90825, USA
- 4. Department of Electrical Engineering, Arizona State University, Tempe, AZ, 85287, USA