Annals of Biomedical Engineering

, Volume 38, Issue 3, pp 1204–1215

Biofluid Mechanics of Special Organs and the Issue of System Control

Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28–30, 2008 Pasadena, California
  • Mair Zamir
  • James E. MooreJr.
  • Hideki Fujioka
  • Donald P. GaverIII
Position Paper

DOI: 10.1007/s10439-010-9902-z

Cite this article as:
Zamir, M., Moore, J.E., Fujioka, H. et al. Ann Biomed Eng (2010) 38: 1204. doi:10.1007/s10439-010-9902-z

Abstract

In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids other than blood and a service other than transport—the lymphatic and pulmonary systems are two striking examples. While transport is still involved in both cases, this is not the only service which they provide and blood is not the only fluid involved. In both systems, filtration, extraction, enrichment, and in general some “treatment” of the fluid itself is the primary function. The study of the systemic circulation has also been conventionally limited to treating the system as if it were an open-loop system governed by the laws of fluid mechanics alone, independent of physiological controls and regulations. This implies that system failures can be explained fully in terms of the laws of fluid mechanics, which of course is not the case. In this paper we examine the clinical implications of these issues and of the special biofluid mechanics issues involved in the lymphatic and pulmonary systems.

Keywords

Lymph Endothelium Edema Ventilator-induced lung injury Respiratory distress syndrome Surfactant Neurovascular control Sudden cardiac death Broken heart syndrome 

Abbreviations

NO

Nitric oxide

ET-1

Endothelin-1

VEGFR-3

Vascular endothelial growth factor receptor 3

Prox-1

Homeobox prospero-like protein

RDS

Respiratory distress syndrome

ALI

Acute lung injury

VILI

Ventilator-induced lung injury

ARDS

Acute respiratory distress syndrome

pCO2

Carbon dioxide partial pressure

Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Mair Zamir
    • 1
    • 2
  • James E. MooreJr.
    • 3
  • Hideki Fujioka
    • 4
  • Donald P. GaverIII
    • 5
  1. 1.Department of Applied MathematicsThe University of Western OntarioLondonCanada
  2. 2.Department of Medical BiophysicsThe University of Western OntarioLondonCanada
  3. 3.Department of Biomedical EngineeringTexas A&M UniversityCollege StationUSA
  4. 4.Center for Computational ScienceTulane UniversityNew OrleansUSA
  5. 5.Department of Biomedical EngineeringTulane UniversityNew OrleansUSA

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