Annals of Biomedical Engineering

, Volume 39, Issue 2, pp 864–883

Quantification of Particle Residence Time in Abdominal Aortic Aneurysms Using Magnetic Resonance Imaging and Computational Fluid Dynamics

  • Ga-Young Suh
  • Andrea S. Les
  • Adam S. Tenforde
  • Shawn C. Shadden
  • Ryan L. Spilker
  • Janice J. Yeung
  • Christopher P. Cheng
  • Robert J. Herfkens
  • Ronald L. Dalman
  • Charles A. Taylor
Article

DOI: 10.1007/s10439-010-0202-4

Cite this article as:
Suh, GY., Les, A.S., Tenforde, A.S. et al. Ann Biomed Eng (2011) 39: 864. doi:10.1007/s10439-010-0202-4

Abstract

Hemodynamic conditions are hypothesized to affect the initiation, growth, and rupture of abdominal aortic aneurysms (AAAs), a vascular disease characterized by progressive wall degradation and enlargement of the abdominal aorta. This study aims to use magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) to quantify flow stagnation and recirculation in eight AAAs by computing particle residence time (PRT). Specifically, we used gadolinium-enhanced MR angiography to obtain images of the vessel lumens, which were used to generate subject-specific models. We also used phase-contrast MRI to measure blood flow at supraceliac and infrarenal locations to prescribe physiologic boundary conditions. CFD was used to simulate pulsatile flow, and PRT, particle residence index, and particle half-life of PRT in the aneurysms were computed. We observed significant regional differences of PRT in the aneurysms with localized patterns that differed depending on aneurysm geometry and infrarenal flow. A bulbous aneurysm with the lowest mean infrarenal flow demonstrated the slowest particle clearance. In addition, improvements in particle clearance were observed with increase of mean infrarenal flow. We postulate that augmentation of mean infrarenal flow during exercise may reduce chronic flow stasis that may influence mural thrombus burden, degradation of the vessel wall, and aneurysm growth.

Keywords

Hemodynamics Pulsatile flow simulation Particle clearance Flow stagnation Flow waveforms Aneurysm geometry Subject-specific 

Abbreviations

AAA

Abdominal aortic aneurysm

AP

Anterior to posterior

IR

Infrarenal

LR

Left to right

MRI

Magnetic resonance imaging

PRI

Particle residence index

PRT

Particle residence time

RCR

Resistance (proximal)–Capacitance–Resistance (distal)

SC

Supraceliac

Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Ga-Young Suh
    • 1
  • Andrea S. Les
    • 2
  • Adam S. Tenforde
    • 2
  • Shawn C. Shadden
    • 3
  • Ryan L. Spilker
    • 4
  • Janice J. Yeung
    • 5
  • Christopher P. Cheng
    • 5
  • Robert J. Herfkens
    • 4
  • Ronald L. Dalman
    • 5
  • Charles A. Taylor
    • 2
  1. 1.Department of Mechanical EngineeringStanford UniversityStanfordUSA
  2. 2.Department of BioengineeringStanford UniversityStanfordUSA
  3. 3.Department of Mechanical and Aerospace EngineeringIllinois Institute of TechnologyChicagoUSA
  4. 4.Department of RadiologyStanford UniversityStanfordUSA
  5. 5.Division of Vascular SurgeryStanford UniversityStanfordUSA

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