Article

Annals of Biomedical Engineering

, Volume 39, Issue 2, pp 884-896

Computational Hemodynamics in Cerebral Aneurysms: The Effects of Modeled Versus Measured Boundary Conditions

  • Alberto MarzoAffiliated withDepartment of Cardiovascular Science, Academic Unit of Medical Physics, Faculty of Medicine and Biomedical Sciences, University of Sheffield Email author 
  • , Pankaj SinghAffiliated withDepartments of Medical Physics and Neurosurgery, Royal Hallamshire Hospital
  • , Ignacio LarrabideAffiliated withCentre for Computational Imaging and Simulation Technologies in Biomedicine, Universitat Pompeu Fabra (UPF)Centre for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)Institució Catalana de Recerca i Estudis Avaçats (ICREA)
  • , Alessandro RadaelliAffiliated withPhilips Healthcare
  • , Stuart ColeyAffiliated withDepartment of Neuroradiology, Royal Hallamshire Hospital
  • , Matt GwilliamAffiliated withMedical Physics and Clinical Engineering, Sheffield Teaching Hospitals NHS
  • , Iain D. WilkinsonAffiliated withDepartment of Human Metabolism, Academic Unit of Radiology, University of Sheffield
  • , Patricia LawfordAffiliated withDepartment of Cardiovascular Science, Academic Unit of Medical Physics, Faculty of Medicine and Biomedical Sciences, University of Sheffield
  • , Philippe ReymondAffiliated withDepartment of Cardiovascular Science, Academic Unit of Medical Physics, Faculty of Medicine and Biomedical Sciences, University of SheffieldLaboratory of Hemodynamics and Cardiovascular Technology (LHCT), École Polytechnique Fédérale de Lausanne
    • , Umang PatelAffiliated withDepartment of Cardiovascular Science, Academic Unit of Medical Physics, Faculty of Medicine and Biomedical Sciences, University of SheffieldDepartment of Neurosurgery, Royal Hallamshire Hospital
    • , Alejandro FrangiAffiliated withCentre for Computational Imaging and Simulation Technologies in Biomedicine, Universitat Pompeu Fabra (UPF)Centre for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)Institució Catalana de Recerca i Estudis Avaçats (ICREA)
    • , D. Rod HoseAffiliated withDepartment of Cardiovascular Science, Academic Unit of Medical Physics, Faculty of Medicine and Biomedical Sciences, University of Sheffield

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Abstract

Modeling of flow in intracranial aneurysms (IAs) requires flow information at the model boundaries. In absence of patient-specific measurements, typical or modeled boundary conditions (BCs) are often used. This study investigates the effects of modeled versus patient-specific BCs on modeled hemodynamics within IAs. Computational fluid dynamics (CFD) models of five IAs were reconstructed from three-dimensional rotational angiography (3DRA). BCs were applied using in turn patient-specific phase-contrast-MR (pc-MR) measurements, a 1D-circulation model, and a physiologically coherent method based on local WSS at inlets. The Navier–Stokes equations were solved using the Ansys®-CFX™ software. Wall shear stress (WSS), oscillatory shear index (OSI), and other hemodynamic indices were computed. Differences in the values obtained with the three methods were analyzed using boxplot diagrams. Qualitative similarities were observed in the flow fields obtained with the three approaches. The quantitative comparison showed smaller discrepancies between pc-MR and 1D-model data, than those observed between pc-MR and WSS-scaled data. Discrepancies were reduced when indices were normalized to mean hemodynamic aneurysmal data. The strong similarities observed for the three BCs models suggest that vessel and aneurysm geometry have the strongest influence on aneurysmal hemodynamics. In absence of patient-specific BCs, a distributed circulation model may represent the best option when CFD is used for large cohort studies.

Keywords

Computational fluid dynamics Phase-contrast MRI 1D circulation model