Bioreactors for Development of Tissue Engineered Heart Valves
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvantages including morbidity associated with long-term anticoagulation and limited durability necessitating repeat operations. The ideal substitute would be widely available and technically implantable for most cardiac surgeons, have normal hemodynamic performance, low risk for structural degeneration, thrombo-embolism and endocarditis, and growth potential for pediatric patients. Tissue engineered heart valves hold promise as a viable substitute to outperform existing valve replacements. An essential component to the development of tissue engineered heart valves is a bioreactor. It is inside the bioreactor that the scaffold and cells are gradually conditioned to the biochemical and mechanical environment of the valve to be replaced.
- American Heart Association Heart Disease and Stroke Statistic 2009 Update. http://www.americanheart.org/presenter.jhtml?identifier=3037327.
- American Heart Association Heart Disease and Stroke Statistics—2005 Update. http://www.americanheart.org/downloadable/heart/1105390918119HDSStats2005Update.pdf.
- Bader, A., G. Steinhoff, K. Strobl, T. Schilling, G. Brandes, H. Mertsching, D. Tsikas, J. Froelich, and A. Haverich. Engineering of human vascular aortic tissue based on a xenogeneic starter matrix. Transplantation 70:7–14, 2000.
- Balachandran, K., P. Sucosky, H. Jo, and A. P. Yoganathan. Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease. Am. J. Physiol. Heart Circ. Physiol. 296:H756–H764, 2009. CrossRef
- Barnett, S. D., and N. Ad. Surgery for aortic and mitral valve disease in the United States: A trend of change in surgical practice between 1998 and 2005. J. Thorac. Cardiovasc. Surg. 137:1422–1429, 2009. CrossRef
- Butcher, J. T., and R. Nerem. Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress. Tissue Eng. 12:905–915, 2006. CrossRef
- Butcher, J. T., A. M. Penrod, A. J. García, and R. M. Nerem. Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arterioscler. Thromb. Vasc. Biol. 24:1429–1434, 2004. CrossRef
- Butcher, J. T., S. Tressel, T. Johnson, D. Turner, G. Sorescu, H. Jo, and R. M. Nerem. Profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arterioscler. Thromb. Vasc. Biol. 26:69–77, 2006. CrossRef
- Cebotari, S., A. Lichtenberg, I. Tudorache, A. Hilfiker, H. Mertsching, R. Leyh, T. Breymann, K. Kallenbach, L. Maniuc, A. Batrinac, O. Repin, O. Maliga, A. Ciubotaru, and A. Haverich. Clinical application of tissue engineered human heart valves using autologous progenitor cells. Circulation 114:1132–1137, 2006. CrossRef
- Dohmen, P. M., A. Lembcke, H. Hotz, D. Kivelitz, and W. F. Konertz. Ross operation with a tissue engineered heart valve. Ann. Thorac. Surg. 74:1438–1442, 2002. CrossRef
- Dohmen, P. M., S. Ozaki, R. Nitsch, J. Yperman, W. Flameng, and W. Konertz. A tissue engineered heart valve implanted in a juvenile sheep model. Med. Sci. Monit. 9:BR137–BR144, 2003.
- Dumont, K., J. Yperman, E. Verbeken, P. Segers, B. Meuris, S. Vandenberghe, W. Flameng, and P. R. Verdonck. Design of a new pulsatile bioreactor for tissue engineered aortic heart valve formation. Artif. Organs 26:710–714, 2002. CrossRef
- Engelmayr, G. C., D. K. Hildebrand, F. W. Sutherland, J. E. Mayer, and M. S. Sacks. A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials. Biomaterials 24:2523–2532, 2003. CrossRef
- Engelmayr, G. C., G. C. Engelmayr, Jr., E. Rabkin, F. W. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks. The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials 26:175–187, 2005. CrossRef
- Engelmayr, Jr., G. C., V. L. Sales, J. E. Mayer, Jr., and M. S. Sacks. Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: implications for engineered heart valve tissues. Biomaterials 27:6083–6095, 2006. CrossRef
- Engelmayr, Jr., G. C., L. Soletti, S. C. Vigmostad, S. G. Budilarto, W. J. Federspiel, K. B. Chandran, D. A. Vorp, and M. S. Sacks. A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology. Ann. Biomed. Eng. 36(5):700–712, 2008. CrossRef
- Grauss, R. W., M. G. Hazekamp, F. Oppenhuizen, C. J. van Munsteren, A. C. Gittenberger-de Groot, and M. C. DeRuiter. Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur. J. Cardiothorac. Surg. 27:566–571, 2005. CrossRef
- Gupta, V., J. A. Werdenberg, B. D. Lawrence, J. S. Mendez, E. H. Stephens, and K. J. Grande-Allen. Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular cells in 3D culture. Ann. Biomed. Eng. 36(7):1092–1103, 2008. CrossRef
- Hilbert, S. L., R. Yanagida, J. Souza, L. Wolfinbarger, A. L. Jones, P. Krueger, G. Stearns, A. Bert, and R. A. Hopkins. Prototype anionic detergent technique used to decellularize allograft valve conduits evaluated in the right ventricular outflow tract in sheep. J. Heart Valve Dis. 13:831–840, 2004.
- Hildebrand, D. K., Z. J. Wu, J. E. Mayer, and M. S. Sacks. Design and hydrodynamic evaluation of a novel pulsatile bioreactor for biologically active heart valves. Ann. Biomed. Eng. 32:1039–1049, 2004. CrossRef
- Hoerstrup, S. P., R. Sodian, S. Daebritz, J. Wang, E. A. Bacha, D. P. Martin, A. M. Moran, K. J. Gulersian, J. S. Sperling, K. Sunjay, J. P. Vacanti, F. J. Schoen, and J. E. Mayer. Functional living trileaflet heart valves grown in vitro. Circulation 102:44–49, 2000.
- Hoerstrup, S. P., R. Sodian, J. S. Sperling, J. P. Vacanti, and J. E. Mayer. New pulsatile bioreactor for in vitro formation of tissue engineered heart valves. Tissue Eng. 6:75–79, 2000. CrossRef
- Hoerstrup, S. P., R. Sodian, S. Daebritz, J. Wang, E. A. Bacha, D. P. Martin, A. M. Moran, K. J. Gulerserian, J. S. Sperling, S. Kashual, J. P. Vacanti, F. J. Schoen, and J. E. Mayer. Functional living trileaflet heart valves grown in vivo. Circulation 102(19 Suppl 3):44–49, 2000.
- Jockenhoevel, S., G. Zund, S. P. Hoerstrup, A. Schnell, and M. Turina. Cardiovascular tissue engineering: a new laminar flow chamber for in vitro improvement of mechanical tissue properties. ASAIO J. 48:8–11, 2002. CrossRef
- Karim, N., K. Golz, and A. Bader. The cardiovascular tissue-reactor: a novel device for the engineering of heart valves. Artif. Organs 30:809–814, 2006. CrossRef
- Kim, W. G., and J. H. Huh. Time related histopathologic changes of acellularized xenogenic pulmonary valved conduits. ASAIO J. 50:601–605, 2004. CrossRef
- Kortsmit, J., M. C. M. Rutten, M. W. Wijlaars, and F. P. T. Baaijens. Deformation-controlled load application in heart valve tissue engineering. Tissue Eng.: Part C 15(4):707–716, 2009.
- Ku, C. H., P. H. Johnson, P. Batten, P. Sarathchandra, R. C. Chambers, P. M. Taylor, M. H. Yacoub, and A. H. Chester. Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. Cardiovasc. Res. 71(3):548–556, 2006. CrossRef
- Leyh, R. G., M. Wilhelmi, T. Walles, K. Kallenbach, P. Rebe, A. Oberbeck, T. Herden, A. Haverich, and H. Mertsching. Acellularized porcine heart valve scaffolds for heart valve tissue engineering and the risk of cross-species transmission of porcine endogenous retrovirus. J. Thorac. Cardiovasc. Surg. 126:1000–1004, 2003. CrossRef
- Lichtenberg, A., I. Tudorache, S. Cebotari, S. Ringes-Lichtenberg, G. Sturz, K. Hoeffler, C. Hurscheler, G. Brandes, A. Hilfiker, and A. Haverich. In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions. Biomaterials 27:4221–4229, 2006. CrossRef
- Lyengar, A. K. S., H. Sugimoto, D. B. Smith, and M. S. Sacks. In vitro quantification of bioprosthetic heart valve leaflet motion using structured light projection. Ann. Biomed. Eng. 29:963–973, 2001. CrossRef
- Merryman, W. D., H. D. Lukoff, R. A. Long, G. C. Engelmayr, Jr., R. A. Hopkins, and M. S. Sacks. Synergistic effects of cyclic tension and transforming growth factor-Β1 on the aortic valve myofibroblast. Cardiovasc. Pathol. 16(5):268–276, 2007. CrossRef
- Mol, A., N. J. Driessen, M. C. Rutten, S. P. Hoerstrup, C. V. Bouten, and F. P. Baaijens. Tissue engineering of human heart valve leaflets: a novel bioreactor for a strain-based conditioning approach. Ann. Biomed. Eng. 33:1778–1788, 2005. CrossRef
- Schenke-Layland, K., F. Opitz, M. Gross, C. Doring, K. J. Halbhuber, F. Schirrmeister, T. Wahlers, and U. A. Stock. Complete dynamic repopulation of decellularized heart valves by application of defined physical signals-an in vitro study. Cardiovasc. Res. 60:497–509, 2003. CrossRef
- Society of Thoracic Surgeons National Cardiac Surgery Database. Available at: http://www.sts.org/documents/pdf/STS-ExecutiveSummaryFall2005.pdf. November 2005.
- Sutherland, F. W., T. E. Perry, Y. Yu, M. C. Sherwood, E. Rabkin, Y. Masuda, G. A. Garcia, D. L. McLellan, G. C. Engelmayr, Jr., M. S. Sacks, F. J. Schoen, and J. E. Mayer, Jr. From stem cells to viable autologous semilunar heart valve. Circulation 111:2783–2791, 2005. CrossRef
- Syedain, Z. H., and R. T. Tranquillo. Controlled cyclic stretch bioreactor for tissue- engineered heart valves. Biomaterials 30(25):4078–4084, 2009. CrossRef
- Vesely, I. Heart valve tissue engineering. Circ. Res. 97:743–755, 2005. CrossRef
- Vesey, J. M., and C. M. Otto. Complications of prosthetic heart valves. Curr. Cardiol. Rep. 6:106–111, 2004. CrossRef
- Weston, M. W., and A. P. Yoganathan. Biosynthetic activity in heart valve leaflets in response to in vitro flow environments. Ann. Biomed. Eng. 29:752–763, 2001. CrossRef
- Weston, M. W., D. V. LaBorde, and A. P. Yoganathan. Estimation of the shear stress on the aortic valve leaflet. Ann. Biomed. Eng. 27:572–579, 1999. CrossRef
- Weyman, A. E. Principles and Practices of Echocardiography. Philadelphia: Lea & Febiger, 1994.
- Zeltinger, J., L. K. Landeen, H. G. Alexander, I. D. Kidd, and B. Sibanda. Development and characterization of tissue-engineered aortic valves. Tissue Eng. 7:9–22, 2001. CrossRef
- Bioreactors for Development of Tissue Engineered Heart Valves
Annals of Biomedical Engineering
Volume 38, Issue 11 , pp 3272-3279
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Heart valves
- Endothelial cells
- Valvular cells
- Industry Sectors
- Author Affiliations
- 1. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
- 2. Wake Forest Institute for Regenerative Medicine, 391 Technology Way, Winston-Salem, NC, 27101, USA
- 3. Department of Cardiothoracic Surgery, Wake Forest University, Medical Center Blvd., Winston-Salem, NC, 27157, USA