Annals of Biomedical Engineering

, Volume 36, Issue 5, pp 852–864

Modeling the Nonlinear Dynamic Interactions of Afferent Pathways in the Dentate Gyrus of the Hippocampus

  • Angelika Dimoka
  • Spiros H. Courellis
  • Vasilis Z. Marmarelis
  • Theodore W. Berger
Article

DOI: 10.1007/s10439-008-9463-6

Cite this article as:
Dimoka, A., Courellis, S.H., Marmarelis, V.Z. et al. Ann Biomed Eng (2008) 36: 852. doi:10.1007/s10439-008-9463-6

Abstract

The dentate gyrus is the first region of the hippocampus that receives and integrates sensory information (e.g., visual, auditory, and olfactory) via the perforant path, which is composed of two distinct neuronal pathways: the Lateral Perforant Path (LPP) and the Medial Perforant Path (MPP). This paper examines the nonlinear dynamic interactions among arbitrary stimulation patterns at these two afferent pathways and their combined effect on the resulting response of the granule cells at the dentate gyrus. We employ non-parametric Poisson–Volterra models that serve as canonical quantitative descriptors of the nonlinear dynamic transformations of the neuronal signals propagating through these two neuronal pathways. These Poisson–Volterra models are estimated in the so-called “reduced form” with experimental data from in vitro hippocampal slices and provide excellent predictions of the electrophysiological activity of the granule cells in response to arbitrary stimulation patterns. The data are acquired through a custom-made multi-electrode-array system, which stimulated simultaneously the two pathways with random impulse trains and recorded the neuronal postsynaptic activity at the granule cell layer. The results of this study show that significant nonlinear interactions exist between the LPP and the MPP that may be critical for the integration of sensory information performed by the dentate gyrus of the hippocampus.

Keyterms

Hippocampus Dentate gyrus Perforant pathway Poisson–Volterra Kernel Laguerre expansion Multi input Multi electrode 

Copyright information

© Biomedical Engineering Society 2008

Authors and Affiliations

  • Angelika Dimoka
    • 1
  • Spiros H. Courellis
    • 2
  • Vasilis Z. Marmarelis
    • 2
  • Theodore W. Berger
    • 2
    • 3
  1. 1.247A Bourns Hall, Department of Bioengineering, Bourns College of EngineeringUniversity of California, RiversideRiversideUSA
  2. 2.Department of Biomedical Engineering, Viterbi School of EngineeringUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.Neuroscience ProgramUniversity of Southern CaliforniaLos AngelesUSA

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