Annals of Biomedical Engineering

, Volume 34, Issue 1, pp 59–74

Nanotechnology for Cell–Substrate Interactions


  • Nathan J. Sniadecki
    • Department of BioengineeringUniversity of Pennsylvania
  • Ravi A. Desai
    • Department of BioengineeringUniversity of Pennsylvania
  • Sami Alom Ruiz
    • Department of BioengineeringUniversity of Pennsylvania
    • Department of Biomedical EngineeringJohns Hopkins University
    • Department of BioengineeringUniversity of Pennsylvania

DOI: 10.1007/s10439-005-9006-3

Cite this article as:
Sniadecki, N.J., Desai, R.A., Ruiz, S.A. et al. Ann Biomed Eng (2006) 34: 59. doi:10.1007/s10439-005-9006-3


In the pursuit to understand the interaction between cells and their underlying substrates, the life sciences are beginning to incorporate micro- and nanotechnology-based tools to probe and measure cells. The development of these tools portends endless possibilities for new insights into the fundamental relationships between cells and their surrounding microenvironment that underlie the physiology of human tissue. Here, we review techniques and tools that have been used to study how a cell responds to the physical factors in its environment. We also discuss unanswered questions that could be addressed by these approaches to better elucidate the molecular processes and mechanical forces that dominate the interactions between cells and their physical scaffolds.


Cell mechanicsCell shapeExtracellular MatrixFocal AdhesionsIntegrinsMechanotransductionMicropatterningNanotopologySelf-Assembled Monolayers (SAMs)Traction Forces

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© Biomedical Engineering Society 2005