Article

Annals of Biomedical Engineering

, Volume 33, Issue 12, pp 1789-1801

First online:

Local Maximal Stress Hypothesis and Computational Plaque Vulnerability Index for Atherosclerotic Plaque Assessment

  • Dalin TangAffiliated withMathematical Sciences Department, Worcester Polytechnic InstituteMathematical Sciences Department, Worcester Polytechnic Institute Email author 
  • , Chun YangAffiliated withMathematical Sciences Department, Worcester Polytechnic InstituteMathematics Department, Beijing Normal University
  • , Jie ZhengAffiliated withMallinkcrodt Institute of Radiology, Washington University
  • , Pamela K. WoodardAffiliated withMallinkcrodt Institute of Radiology, Washington University
  • , Jeffrey E. SaffitzAffiliated withDepartment of Pathology, Washington University
  • , Joseph D. PetruccelliAffiliated withMathematical Sciences Department, Worcester Polytechnic Institute
  • , Gregorio A. SicardAffiliated withDepartment of Surgery, Washington University
  • , Chun YuanAffiliated withDeparment of Radiology, University of Washington

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Abstract

It is believed that atherosclerotic plaque rupture may be related to maximal stress conditions in the plaque. More careful examination of stress distributions in plaques reveals that it may be the local stress/strain behaviors at critical sites such as very thin plaque cap and locations with plaque cap weakness that are more closely related to plaque rupture risk. A “local maximal stress hypothesis” and a stress-based computational plaque vulnerability index (CPVI) are proposed to assess plaque vulnerability. A critical site selection (CSS) method is proposed to identify critical sites in the plaque and critical stress conditions which are be used to determine CPVI values. Our initial results based on 34 2D MRI slices from 14 human coronary plaque samples indicate that CPVI plaque assessment has an 85% agreement rate (91% if the square root of stress values is used) with assessment given by histopathological analysis. Large-scale and long-term patient studies are needed to further validate our findings for more accurate quantitative plaque vulnerability assessment.

Keywords

Stroke Heart attack Plaque cap rupture Fluid-structure interaction Carotid artery Coronary Blood flow Cardiovascular diseases