Microfluidics and Nanofluidics

, Volume 15, Issue 5, pp 647–659

Software-programmable continuous-flow multi-purpose lab-on-a-chip

Authors

    • Microfluidic Innovations
    • School of Electrical and Computer EngineeringPurdue University
  • Raviraj Thakur
    • Birck Nanotechnology Center, School of Mechanical EngineeringPurdue University
  • Seth Madren
    • Department of ChemistryIndiana University
  • Han-Sheng Chuang
    • Department of Biomedical EngineeringNational Cheng Kung University
  • Mithuna Thottethodi
    • School of Electrical and Computer EngineeringPurdue University
  • T. N. Vijaykumar
    • School of Electrical and Computer EngineeringPurdue University
  • Steven T. Wereley
    • Birck Nanotechnology Center, School of Mechanical EngineeringPurdue University
  • Stephen C. Jacobson
    • Department of ChemistryIndiana University
Research Paper

DOI: 10.1007/s10404-013-1180-2

Cite this article as:
Amin, A.M., Thakur, R., Madren, S. et al. Microfluid Nanofluid (2013) 15: 647. doi:10.1007/s10404-013-1180-2

Abstract

Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmableLab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

Copyright information

© Springer-Verlag Berlin Heidelberg 2013