Microfluidics and Nanofluidics

, Volume 15, Issue 5, pp 647–659

Software-programmable continuous-flow multi-purpose lab-on-a-chip

  • Ahmed M. Amin
  • Raviraj Thakur
  • Seth Madren
  • Han-Sheng Chuang
  • Mithuna Thottethodi
  • T. N. Vijaykumar
  • Steven T. Wereley
  • Stephen C. Jacobson
Research Paper

DOI: 10.1007/s10404-013-1180-2

Cite this article as:
Amin, A.M., Thakur, R., Madren, S. et al. Microfluid Nanofluid (2013) 15: 647. doi:10.1007/s10404-013-1180-2

Abstract

Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmableLab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Ahmed M. Amin
    • 1
    • 2
  • Raviraj Thakur
    • 3
  • Seth Madren
    • 4
  • Han-Sheng Chuang
    • 5
  • Mithuna Thottethodi
    • 2
  • T. N. Vijaykumar
    • 2
  • Steven T. Wereley
    • 3
  • Stephen C. Jacobson
    • 4
  1. 1.Microfluidic InnovationsWest LafayetteUSA
  2. 2.School of Electrical and Computer EngineeringPurdue UniversityWest LafayetteUSA
  3. 3.Birck Nanotechnology Center, School of Mechanical EngineeringPurdue UniversityWest LafayetteUSA
  4. 4.Department of ChemistryIndiana UniversityBloomingtonUSA
  5. 5.Department of Biomedical EngineeringNational Cheng Kung UniversityTainanTaiwan