The influence of magnetic carrier size on the performance of microfluidic integrated micro-electromagnetic traps
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- Le Drogoff, B., Clime, L. & Veres, T. Microfluid Nanofluid (2008) 5: 373. doi:10.1007/s10404-007-0249-1
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Efficient manipulation and capture of magnetic carriers in fluid stream require appropriate magnetic confinement devices whose performances are strongly dependent on the nature of the magnetic carriers. In this sense, we have performed a systematic investigation of the magnetic capture efficiencies for five commercially available superparamagnetic particles pumped along rectangular microfluidic channels using microelectromagnetic traps composed of planar circular current-carrying microwires and cylindrical ferromagnetic posts. In addition, in order to obtain a quantitative description of particle movement, we have implemented a numerical model for the dynamics of magnetic objects subjected to magnetic field gradients in conventional continuous-flow microfluidic devices. Fully 3D trajectories of the particles, effective cross-sectional areas of the microchannel as well as micro-electromagnet trapping efficiencies are compared to experimental measurements and a very good agreement is obtained. Finally, a simple and effective analytical model to determine the critical velocity, i.e. when the magnetic trapping device is no longer able to capture and hold 100% of the magnetic superparamagnetic particles, is also presented.