Towards a Case Definition for Devil Facial Tumour Disease: What Is It?
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In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.
- Towards a Case Definition for Devil Facial Tumour Disease: What Is It?
Volume 4, Issue 3 , pp 346-351
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- Print ISSN
- Online ISSN
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- Tasmanian devil
- Sarcophilus harrisii
- facial tumour
- Author Affiliations
- 1. Department of Primary Industries and Water, Animal Health Laboratories, Diagnostic Services Branch, PO Box 46, Kings Meadows, TAS 7249, Australia
- 2. Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, The University of Sydney, New South Wales, Australia
- 3. Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria, Australia
- 4. CSIRO Textile and Fibre Technology, Clayton, Victoria, Australia