EcoHealth

, 4:346

Towards a Case Definition for Devil Facial Tumour Disease: What Is It?

Authors

    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Anne-Maree Pearse
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Richmond Loh
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Kate Swift
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Kathy Belov
    • Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary ScienceThe University of Sydney
  • Nolan Fox
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Erin Noonan
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Dane Hayes
    • Department of Primary Industries and WaterAnimal Health Laboratories, Diagnostic Services Branch
  • Alex Hyatt
    • Australian Animal Health LaboratoryCSIRO Livestock Industries
  • Lingfa Wang
    • Australian Animal Health LaboratoryCSIRO Livestock Industries
  • David Boyle
    • Australian Animal Health LaboratoryCSIRO Livestock Industries
  • Jeff Church
    • CSIRO Textile and Fibre Technology
  • Debra Middleton
    • Australian Animal Health LaboratoryCSIRO Livestock Industries
  • Robert Moore
    • Australian Animal Health LaboratoryCSIRO Livestock Industries
Special Focus: Tasmanian Devil Declines

DOI: 10.1007/s10393-007-0126-0

Cite this article as:
Pyecroft, S.B., Pearse, A., Loh, R. et al. EcoHealth (2007) 4: 346. doi:10.1007/s10393-007-0126-0

Abstract

In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.

Keywords

Tasmanian devilSarcophilus harrisiineoplasmkaryotypefacial tumourneuroendocrine

Copyright information

© Ecohealth Journal Consortium 2007