Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association
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To determine whether there is a significant association between human immunodeficiency virus (HIV)-related retinal microangiopathy and systemic cytomegalovirus (CMV) disease in HIV-infected patients.
Participants in this single-center, cross-sectional, retrospective study were 383 HIV-infected patients assessed for ocular manifestations before the beginning of antiretroviral therapy. The presence of HIV-related retinal microangiopathy, the presence of systemic CMV disease, laboratory data, and demographic information were determined by referring to medical records. The significance of any association between HIV-related retinal microangiopathy and systemic CMV disease was determined by use of the Chi-squared test and by multivariate analysis.
HIV-related retinal microangiopathy was present in 85 patients, and was significantly associated with systemic CMV disease both by use of the Chi-squared test (P = 0.006) and by multivariate analysis (P = 0.045, odds ratio 2.03, 95 % confidence interval 1.02–4.06 adjusted for CD4+ cell count and plasma HIV-RNA level).
These findings indicate that microangiopathy may be involved in the development of CMV disease in HIV-infected patients. Thus, detection of the presence of HIV-related retinal microangiopathy is important in the management of HIV-infected patients.
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- Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association
Japanese Journal of Ophthalmology
Volume 57, Issue 4 , pp 372-378
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Cotton-wool spots
- Human immunodeficiency virus
- Acquired immune deficiency syndrome
- Industry Sectors
- Author Affiliations
- 1. Department of Ophthalmology, Tokyo Metropolitan Komagome Hospital, 18-22, Honkomagome 3chome, Bunkyo, Tokyo, 113-0021, Japan
- 3. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo, Japan
- 4. Clinical Research Center, Tokyo Medical and Dental University, Bunkyo, Japan
- 2. Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Bunkyo, Japan