Japanese Journal of Ophthalmology

, Volume 57, Issue 2, pp 211–220

Two-year results of combined intravitreal anti-VEGF agents and photodynamic therapy for retinal angiomatous proliferation

Clinical Investigation

DOI: 10.1007/s10384-012-0215-7

Cite this article as:
Saito, M., Iida, T. & Kano, M. Jpn J Ophthalmol (2013) 57: 211. doi:10.1007/s10384-012-0215-7



To clarify the efficacy of a combination of intravitreal anti-vascular endothelial growth factor (VEGF) injections and photodynamic therapy (PDT), over 24 months, for patients with symptomatic retinal angiomatous proliferation (RAP).


We retrospectively reviewed 13 treatment-naïve eyes of 12 patients (7 men, 5 women; age range (mean), 63–92 (77) years) treated with intravitreal bevacizumab (IVB) plus PDT as initial treatment. Retreatment was performed with IVB plus PDT until February 2009 or intravitreal ranibizumab and PDT from March 2009.


Mean best-corrected visual acuity (BCVA) significantly improved from 0.26 at baseline to 0.40 at 24 months (P = 0.013). The mean improvement in BCVA at 24 months from baseline was 1.79 lines. The central retinal thickness decreased significantly from 431 to 142 microns at 24 months (P < 0.0001). Complete occlusion of the retinal–retinal anastomosis was achieved in seven of the 10 eyes at 24 months. The mean number of PDT treatments during 24 months was 2.8 and the mean number of injections was 3.4. Geographic atrophy was seen in four eyes without significant decline of VA at 24 months.


Combined anti-VEGF and PDT for RAP patients effectively maintained or improved VA and reduced exudation, without severe adverse events, over 24 months.


Retinal angiomatous proliferation Bevacizumab Ranibizumab Photodynamic therapy Age-related macular degeneration 

Copyright information

© Japanese Ophthalmological Society 2012

Authors and Affiliations

  1. 1.Department of OphthalmologyFukushima Medical University School of MedicineFukushimaJapan
  2. 2.Department of OphthalmologyTokyo Women’s Medical University School of MedicineTokyoJapan

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