Japanese Journal of Ophthalmology

, Volume 56, Issue 6, pp 577–583

Novel automated screening of age-related macular degeneration

  • Yasuyuki Yamauchi
  • Hiroyuki Kemma
  • Hiroshi Goto
  • Atsushi Nakamura
  • Takashi Nagaoka
  • Takayuki Sota
Clinical Investigation

DOI: 10.1007/s10384-012-0184-x

Cite this article as:
Yamauchi, Y., Kemma, H., Goto, H. et al. Jpn J Ophthalmol (2012) 56: 577. doi:10.1007/s10384-012-0184-x

Abstract

Purpose

To determine the objective and quantitative hyperspectral parameters for distinguishing between age-related macular degeneration (AMD) and a normal macula.

Methods

Near-infrared hyperspectral images were taken of 71 eyes of 62 AMD patients with exudative AMD and 21 eyes of 12 control subjects without AMD. The spatial information included a 480 × 321-pixel image in a 50° field located at the ocular fundus and a 720–950-nm-per-pixel reflectance spectrum. Macular vectors were determined as the average spectrum for each macula, and reference vectors were used as average macular vectors for healthy volunteers. Variations in vector length and angle were calculated based on comparison with the reference vector. The AMD differentiation index was a parameter that minimized the plot overlap between AMD patients and controls.

Results

Statistically significant differences between the AMD patients and controls were noted. Receiver-operating characteristic curve analysis revealed an area under the curve of 0.888. The appropriate threshold values were attained for the proposed discrimination index, including 68 % sensitivity, 95 % specificity and 74 % accuracy.

Conclusions

This study presents a simplified diagnostic index for the determination of age-related macular degeneration based on near-infrared spectra.

Keywords

Age-related macular degeneration Near-infrared hyperspectral imaging Automated method for screening 

Copyright information

© Japanese Ophthalmological Society 2012

Authors and Affiliations

  • Yasuyuki Yamauchi
    • 1
    • 3
  • Hiroyuki Kemma
    • 2
  • Hiroshi Goto
    • 1
  • Atsushi Nakamura
    • 2
  • Takashi Nagaoka
    • 4
  • Takayuki Sota
    • 2
  1. 1.Department of OphthalmologyTokyo Medical University HospitalTokyoJapan
  2. 2.Department of Electrical Engineering and BioscienceWaseda UniversityTokyoJapan
  3. 3.Department of OphthalmologyToda Chuo General HospitalSaitamaJapan
  4. 4.Institute for Science and EngineeringWaseda UniversityTokyoJapan