Classic choroidal neovascularization developing after photodynamic therapy in eyes with polypoidal choroidal vasculopathy

  • Mitsuhiro Imasawa
  • Yoichi Sakurada
  • Hiroyuki Iijima
Clinical Investigation

DOI: 10.1007/s10384-011-0006-6

Cite this article as:
Imasawa, M., Sakurada, Y. & Iijima, H. Jpn J Ophthalmol (2011) 55: 241. doi:10.1007/s10384-011-0006-6

Abstract

Purpose

To investigate the characteristics of eyes with polypoidal choroidal vasculopathy (PCV) which develop secondary classic choroidal neovascularization (CNV) after photodynamic therapy (PDT).

Methods

We retrospectively reviewed the records of 64 eyes of 64 PCV patients (43 men, 21 women; mean age ± standard deviation, 72.7 ± 8.6 years), who were followed-up for at least 1 year after the initial PDT. There was no evidence of classic CNV in any of the subject eyes on fluorescein angiography (FA) at the first PDT. Eyes which developed of secondary classic CNV after PDT were classified as the CNV group and the other eyes as the No-CNV group.

Results

Secondary classic CNV developed after PDT in 10 (15.6%) of the 64 eyes. Six patients developed CNV within 1 year after the first PDT. Multivariate logistic regression analysis for the baseline factors related to CNV development, including age, gender, greatest linear dimension, and the lesion components, revealed that in the CNV group the age was significantly younger (p = 0.037) and the incidence of retinal edema was significantly greater (p = 0.041) than in the No-CNV group.

Conclusions

Secondary classic CNV tends to develop after PDT in PCV eyes in younger patients with retinal edema.

Keywords

Classic choroidal neovascularization Photodynamic therapy Polypoidal choroidal vasculopathy Risk factors 

Copyright information

© Japanese Ophthalmological Society 2011

Authors and Affiliations

  • Mitsuhiro Imasawa
    • 1
  • Yoichi Sakurada
    • 1
  • Hiroyuki Iijima
    • 1
  1. 1.Department of Ophthalmology, Faculty of MedicineUniversity of YamanashiChuoJapan