Japanese Journal of Ophthalmology

, Volume 50, Issue 2, pp 85–89

Tear Film Break-up Time Evaluated by Real-Time Hartmann-Shack Wavefront Sensing

Authors

  • Toshifumi Mihashi
    • Department of Applied Visual ScienceOsaka University Graduate School of Medicine
    • Technical Research InstituteTopcon Corporation
  • Yoko Hirohara
    • Department of Applied Visual ScienceOsaka University Graduate School of Medicine
    • Technical Research InstituteTopcon Corporation
  • Shizuka Koh
    • Department of OphthalmologyOsaka University Graduate School of Medicine
  • Sayuri Ninomiya
    • Department of Applied Visual ScienceOsaka University Graduate School of Medicine
  • Naoyuki Maeda
    • Department of OphthalmologyOsaka University Graduate School of Medicine
    • Department of Applied Visual ScienceOsaka University Graduate School of Medicine
LABORATORY INVESTIGATION

DOI: 10.1007/s10384-005-0289-6

Cite this article as:
Mihashi, T., Hirohara, Y., Koh, S. et al. Jpn J Ophthalmol (2006) 50: 85. doi:10.1007/s10384-005-0289-6

Abstract

Purpose

To develop a novel method for measuring tear break-up time (BUT) by continuously measuring higher order wavefront aberrations using a Hartmann-Shack (H-S) aberrometer.

Methods

Wavefront aberrations up to the sixth order for a 4-mm pupil were measured in six eyes of six normal subjects using an H-S aberrometer. The aberrometry was performed once every second for up to 50 s under topical anesthesia. The sequence of the points was divided into two stages, and the BUT was defined as the wavefront border of the stages (WFBUT). The WFBUT was compared with the BUT by the conventional fluorescein method (FLBUT) or by the disruption of placid-ring images (PLBUT).

Results

In three eyes, the WFBUT (average, 10.9 ± 1.1 s) was shorter than the PLBUT (average, 17.5 ± 2.5 s), while in the other three eyes the WFBUT (average, 21.5 ± 2.2 s) was longer than PLBUT (average, 8.1 ± 2.2 s). The FLBUT was shorter than WFBUT or PLBUT in most cases.

Conclusions

The tear break-up time measured by H-S aberrometer may be used as a practical measure of tear break-up. Jpn J Ophthalmol 2006;50:85–89 © Japanese Ophthalmological Society 2006

Key words

aberrationbreak-up timeHartmann-Shack aberrometertear film

Copyright information

© Japanese Ophthalmological Society 2006