Japanese Journal of Ophthalmology

, Volume 50, Issue 1, pp 7–11

Human Herpesvirus-8 in Kaposi's Sarcoma of the Conjunctiva in a Patient with AIDS


    • Department of OphthalmologyTokyo Medical University
  • Norio Usui
    • Shinkawabashi Hospital
  • Tetsutaro Sata
    • Department of PathologyNational Institute of Infectious Diseases
  • Harutaka Katano
    • Department of PathologyNational Institute of Infectious Diseases
  • Hiromi Serizawa
    • Department of PathologyTokyo Medical University
  • Shinya Okada
    • Department of PathologyTokyo Medical University

DOI: 10.1007/s10384-005-0268-y

Cite this article as:
Minoda, H., Usui, N., Sata, T. et al. Jpn J Ophthalmol (2006) 50: 7. doi:10.1007/s10384-005-0268-y



To demonstrate human herpesvirus-8 (HHV-8) in Kaposi's sarcoma (KS) of the conjunctiva in a patient with acquired immunodeficiency syndrome (AIDS).


Clinical observation, pathologic findings of conjunctival specimens, immunohistochemical staining for HHV-8-specific antigen, polymerase chain reaction (PCR) analysis of HHV-8 DNA, and detection of specific antibody in patient's serum at appropriate times.


In the conjunctival specimen, swollen endothelial-like cells were found with slit-like vessels. CD 31-positive cells were noted on the inner surface of the slit-like vessels, and HHV-8 latency-associated nuclear antigen was detected. The presence of HHV-8 DNA was demonstrated by PCR. Anti-HHV-8 antibody was found in the patient's serum.


This is the first case report in the ophthalmology literature that provides histological, DNA, and serological evidence that HHV-8 is involved in the pathogenesis of conjunctival KS. Jpn J Ophthalmol 2006;50:7–11 © Japanese Ophthalmological Society 2006

Key words

AIDSconjunctivahuman herpesvirus-8Kaposi's sarcomalatency-associated nuclear antigen

Copyright information

© Japanese Ophthalmological Society 2006