, Volume 161, Issue 21-22, pp 505-510
Date: 04 Apr 2011

Circulating retinol-binding protein 4 and metabolic syndrome in the elderly

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Zusammenfassung

Eine Reihe von Studien beschreit die Abhängigkeit der Retinol-bindendes Protein 4 (RBP4)-Konzentration von Alter und Adipositas, allerdings nur wenige dieser Studien wurden bei älteren Personen durchgeführt. Aus diesem Grund untersuchten wir in einer großen, bevölkerungsbezogenen Studie (VITA) die Korrelation zwischen RBP4-Konzentration und Komponenten des Type-2-Diabetes/metabolischen Syndroms (MetS). Untersucht wurden Body-Mass-Index, Blutdruck, Lipidparameter, Nüchternglukose, Insulin, HOMA-IR und Rauchgewohnheiten in ausschließlich 75- bis 76-jährigen Probanden (N = 232). In dieser Studie lag eine Korrelation zwischen RBP4-Konzentration und Komponenten des Typ-2-Diabetes/MetS vor, wobei diese bei Triglyzeride und HDL am stärksten war (p<0,0001). Zusammenfassend spielt RBP4 eine Rolle in den Biomechanismen, die für die Entstehung von Insulinresistenz und Type-2-Diabetes verantwortlich sind.

Summary

BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. METHODS: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75–76 year old participants (N = 232). RESULTS: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (p<0.0001). CONCLUSIONS: RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.

Nazanin Mostafaie and Christian Sebesta: these authors equally contributed to this work