Associations Between Exercise, Quality of Life, and Fatigue in Colorectal Cancer Survivors
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
This study was designed to examine quality of life and fatigue in colorectal cancer survivors meeting and not meeting public health exercise guidelines.
A Canadian provincial cancer registry identified colorectal cancer survivors who were mailed a questionnaire that assessed self-reported exercise, quality of life (Functional Assessment of Cancer Therapy - Colorectal), fatigue, medical, and demographic variables.
Completed questionnaires were received from 413 (61.3 percent) eligible colorectal cancer survivors. Only 25.9 percent of colorectal cancer survivors reported meeting exercise guidelines. Colorectal cancer survivors meeting public health exercise guidelines reported clinically and significantly better quality of life (mean difference, 6; 95 percent confidence interval, 2.3–9.8; P = 0.002) and fatigue (mean difference = 5.2; 95 percent confidence interval, 2.9–7.5; P < 0.001). Differences remained after adjusting for medical and demographic factors. Cancer site (i.e., colon vs. rectal) was the only variable to moderate this association (P < 0.05 for interaction).
Colorectal cancer survivors meeting public health exercise guidelines reported significantly and meaningfully better quality of life and fatigue scores than colorectal cancer survivors who did not meet guidelines. Prospective observational studies and randomized, controlled trials are needed to further assess the causal nature of these relationships.
- Cancer Facts and Figures 2006. Atlanta: American Cancer Society; 2006. Available at: http://www.cancer.org/downloads/STT/CAFF2006PWSecured.pdf. Accessed December 4, 2007.
- Johnston L. Colon & rectal cancer. Sebastopol: O’Reilly & Associates, Inc., 2000.
- Courneya K, Friedenreich CM, Quinney HA, Jones LW, Friedenreich CM, Arthur K. A randomized trial of exercise and quality of life in colorectal cancer survivors. Eur J Cancer Care 2003;12:347–57. CrossRef
- Courneya K, Friedenreich CM, Arthur K, Bobick TM. Physical exercise and quality of life in postsurgical colorectal cancer patients. Psychol Health Med 1999;4:181–7. CrossRef
- Courneya K, Friedenreich CM. Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med 1997;3:215–26. CrossRef
- Doyle C, Kushi LH, Byers T, et al. Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 2006;56:323–53. CrossRef
- Peddle CJ, Plotnikoff RC, Wild TC, Au HJ, Courneya KS. Medical, demographic, and psychosocial correlates of exercise in colorectal cancer survivors: an application of self-determination theory. Support Care Cancer 2008;16:9–17.
- Pakilit A, Kahn BA, Petersen L, Abraham LS, Greendale GA, Ganz PA. Making effective use of tumor registries for cancer survivorship research. Cancer 2001;92:1305–14. CrossRef
- Courneya K, Friedenreich CM. Determinants of exercise during colorectal cancer treatment: An application of the theory of planned behavior. Oncol Nurs Forum 1997;24:1715–23.
- Dillman W, Bergsagel PL, Duehl WM, et al. Mail and other self administered questionnaires. In: Rossi J, Anderson AB. Handbook of survey research. Toronto: Academic Press, 2001:359–78.
- Randsdell L. Maximizing response rate in questionnaire research. Am J Health Behav 1996;20:50–6.
- Godin G, Shepard RJ. A simple method to assess exercise behavior in the community. Can J App Sport Sci 1985;10:141–6.
- Godin G, Jobin J, Bouillon J. Assessment of leisure time exercise behavior by self-report: a concurrent validity study. Can J Public Health 1986;77:359–61.
- Jacobs D, Ainsworth BE, Hartman TJ, Leon AS. A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc 1993;25:81–91. CrossRef
- Lynch BM, Owen N, Newman B, et al. Reliability of a measure of prediagnosis physical activity for cancer survivors. Med Sci Sports Exerc 2006;38:715–9. CrossRef
- Pate R, Pratt M, Blair SN, et al. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402–7. CrossRef
- Ward W, Hahn EA, Mo F, Hernandez L, Tulsky DS, Cella D. Reliability and validity of the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) quality of life instrument. Qual Life Res 1999;8:181–95. CrossRef
- Cella D, Eton DT, Lai JS, Peterman AH, Merkel D. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage 2002;24:547–61. CrossRef
- Cella D, Tulsky DS, Gray G, et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 1993;11:570–9.
- Courneya K, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: Cardiopulmonary and quality of life outcomes. J Clin Oncol 2003;21:1660–8. CrossRef
- Segal R, Reid RD, Courneya KS, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 2003;21:1653–9. CrossRef
- Courneya KS, Friedenreich CM, Quinney HA, Fields AL, Jones LW, Fairey AS. A randomized trial of exercise and quality of life in colorectal cancer survivors. Eur J Cancer Care (Engl) 2003;12:347–57. CrossRef
- Bellizzi KM, Rowland JH, Jeffery DD, McNeel T. Health behaviors of cancer survivors: examining opportunities for cancer control intervention. J Clin Oncol 2005;23:8884–93. CrossRef
- Coups EJ, Ostroff JS. A population-based estimate of the prevalence of behavioral risk factors among adult cancer survivors and noncancer controls. Prev Med 2005;40:702–11. CrossRef
- Burgess J, Berry TR, Spence JC. 2007 Alberta Survey on Physical Activity: a concise report. Edmonton: Alberta Centre for Active Living; 2007. Available at: http://www.centre4activeliving.ca/publications/physact_survey/2007report.pdf. Accessed December 4, 2007.
- Courneya K, Friedenreich CM. Relationship between exercise during treatment and current quality of life among survivors of breast cancer. J Psychosoc Oncol 1997;15:35–57. CrossRef
- Karvinen KH, Courneya KS, Campbell KL, et al. Exercise preferences of endometrial cancer survivors: a population-based study. Cancer Nurs 2006;29:259–65. CrossRef
- Vallance J, Courneya KS, Jones LW, Reiman T. Differences in quality of life between non-Hodgkin’s lymphoma survivors meeting and not meeting public health exercise guidelines. Psychooncology 2005;14:979–91. CrossRef
- Meyerhardt JA, Giovannucci EL, Holmes MD, et al. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol 2006;24:3527–34. CrossRef
- Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 2006;24:3535–41. CrossRef
- Yost KJ, Cella D, Chawla A, et al. Minimally important differences were estimated for the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) instrument using a combination of distribution- and anchor-based approaches. J Clin Epidemiol 2005;58:1241–51. CrossRef
- Jones LW, Courneya KS, Vallance JK, et al. Association between exercise and quality of life in multiple myeloma cancer survivors. Support Care Cancer 2004;12:780–8. CrossRef
- Courneya K. Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc 2003;35:1846–52. CrossRef
- Courneya KS, Karvinen KH, Campbell KL, et al. Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol 2005;97:422–30. CrossRef
- Dimeo F, Rumberger BG, Keul J. Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 1998;30:375–8.
- Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 2005;23:3830–42. CrossRef
- Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R. Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2005;14:1588–95. CrossRef
- Losito J, Murphy S, Thomas M. The effects of group exercise on fatigue and quality of life during cancer treatment. Oncol Nurs Forum 2006;33:821–5. CrossRef
- van Weert E, Hoekstra-Weebers J, Otter R, Postema K, Sanderman R, van der Schans C. Cancer-related fatigue: predictors and effects of rehabilitation. Oncologist 2006;11:184–96. CrossRef
- Associations Between Exercise, Quality of Life, and Fatigue in Colorectal Cancer Survivors
Diseases of the Colon & Rectum
Volume 51, Issue 8 , pp 1242-1248
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Colorectal cancer
- Quality of life
- Physical activity
- Industry Sectors
- Author Affiliations
- 1. Faculty of Physical Education and Recreation, University of Alberta, E-488 Van Vliet Center, Edmonton, Alberta, T6G 2H9, Canada
- 2. Division of Medical Oncology, Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada