Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

  • Torben Dannhauer
  • Martina Sattler
  • Wolfgang Wirth
  • David J. Hunter
  • C. Kent Kwoh
  • Felix Eckstein
Research Article

DOI: 10.1007/s10334-013-0418-z

Cite this article as:
Dannhauer, T., Sattler, M., Wirth, W. et al. Magn Reson Mater Phy (2014) 27: 339. doi:10.1007/s10334-013-0418-z

Abstract

Object

Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.

Materials and methods

Of 625 “Osteoarthritis Initiative” participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33 % femoral length (distal to proximal).

Results

In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was −2.8 ± 7.9 % (standardized response mean [SRM] = −0.35), and it was −1.8 ± 6.8 % (SRM = −0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (−3.9 ± 20 %; SRM = −0.20) and in non-progressive controls (−4.5 ± 28 %; SRM = −0.16).

Conclusion

MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

Keywords

Quadriceps muscleCross-sectional anatomyMuscle strengthLongitudinal studiesSensitivity

Copyright information

© ESMRMB 2013

Authors and Affiliations

  • Torben Dannhauer
    • 1
    • 2
  • Martina Sattler
    • 1
  • Wolfgang Wirth
    • 1
    • 2
  • David J. Hunter
    • 3
  • C. Kent Kwoh
    • 4
  • Felix Eckstein
    • 1
    • 2
  1. 1.Institute of Anatomy and Musculoskeletal ResearchParacelsus Medical UniversitySalzburgAustria
  2. 2.Chondrometrics GmbHAinringGermany
  3. 3.Royal North Shore Hospital and Northern Clinical SchoolUniversity of SydneySydneyAustralia
  4. 4.Division of Rheumatology and Clinical ImmunologyUniversity of PittsburghPittsburghUSA