A historical perspective on the evolution of resting-state functional connectivity with MRI

Review Article

DOI: 10.1007/s10334-010-0230-y

Cite this article as:
Lowe, M.J. Magn Reson Mater Phy (2010) 23: 279. doi:10.1007/s10334-010-0230-y


In this review article, I discuss initial and recent studies of the assessment of functional connectivity in the human brain using low-frequency BOLD fluctuations in the resting state. By putting the studies in their historical context, the goal is to give the reader an appreciation of the evolution of the field and the pivotal events and studies that have led to the widespread acceptance of the method as a neuroscience tool for investigating functional connectivity in the human brain.


Functional connectivity Resting state fMRI Anatomic connectivity Default mode 

Copyright information

© ESMRMB 2010

Authors and Affiliations

  1. 1.Cleveland Clinic FoundationClevelandUSA