Magnetic Resonance Materials in Physics, Biology and Medicine

, 20:273

Magnetic resonance elastography compared with rotational rheometry for in vitro brain tissue viscoelasticity measurement

Authors

  • Jonathan Vappou
    • Institut de mécanique des fluides et des solidesUMR 7507 CNRS-Université Louis Pasteur
  • Elodie Breton
    • Service de biophysique et médecine nucléaireCHRU Hautepierre
  • Philippe Choquet
    • Service de biophysique et médecine nucléaireCHRU Hautepierre
  • Christian Goetz
    • Service de biophysique et médecine nucléaireCHRU Hautepierre
  • Rémy Willinger
    • Institut de mécanique des fluides et des solidesUMR 7507 CNRS-Université Louis Pasteur
    • Service de biophysique et médecine nucléaireCHRU Hautepierre
Research Article

DOI: 10.1007/s10334-007-0098-7

Cite this article as:
Vappou, J., Breton, E., Choquet, P. et al. Magn Reson Mater Phy (2007) 20: 273. doi:10.1007/s10334-007-0098-7

Abstract

Magnetic resonance elastography (MRE) is an increasingly used method for non-invasive determination of tissue stiffness. MRE has shown its ability to measure in vivo elasticity or viscoelasticity depending on the chosen rheological model. However, few data exist on quantitative comparison of MRE with reference mechanical measurement techniques. MRE has only been validated on soft homogeneous gels under both Hookean elasticity and linear viscoelasticity assumptions, but comparison studies are lacking concerning viscoelastic properties of complex heterogeneous tissues. In this context, the present study aims at comparing an MRE-based method combined with a wave equation inversion algorithm to rotational rheometry. For this purpose, experiments are performed on in vitro porcine brain tissue. The dynamic behavior of shear storage (G- and loss (G) moduli obtained by both rheometry and MRE at different frequency ranges is similar to that of linear viscoelastic properties of brain tissue found in other studies. This continuity between rheometry and MRE results consolidates the quantitative nature of values found by MRE in terms of viscoelastic parameters of soft heterogeneous tissues. Based on these results, the limits of MRE in terms of frequency range are also discussed.

Keywords

Magnetic resonance elastographyLinear viscoelasticityPhase encodingBrain biomechanics

Copyright information

© ESMRMB 2007