Magnetic Resonance Materials in Physics, Biology and Medicine

, Volume 19, Issue 4, pp 180–186

High proton relaxivity for gadolinium oxide nanoparticles

Authors

    • CMIVLinköping University
    • Department of RadiologyLinköping University
  • Anna Klasson
    • CMIVLinköping University
    • Department of RadiologyLinköping University
  • Henrik Pedersen
    • Department of Physics, Chemistry and BiologyLinköping University
  • Cecilia Vahlberg
    • Department of Physics and Measurement Technology/Applied PhysicsLinköping University
  • Per-Olov Käll
    • Department of Physics, Chemistry and BiologyLinköping University
  • Kajsa Uvdal
    • Department of Physics and Measurement Technology/Applied PhysicsLinköping University
Research Article

DOI: 10.1007/s10334-006-0039-x

Cite this article as:
Engström, M., Klasson, A., Pedersen, H. et al. Magn Reson Mater Phy (2006) 19: 180. doi:10.1007/s10334-006-0039-x

Abstract

Objective: Nanosized materials of gadolinium oxide can provide high-contrast enhancement in magnetic resonance imaging (MRI). The objective of the present study was to investigate proton relaxation enhancement by ultrasmall (5 to 10 nm) Gd2O3 nanocrystals.

Materials and methods: Gd2O3 nanocrystals were synthesized by a colloidal method and capped with diethylene glycol (DEG). The oxidation state of Gd2O3 was confirmed by X-ray photoelectron spectroscopy. Proton relaxation times were measured with a 1.5-T MRI scanner. The measurements were performed in aqueous solutions and cell culture medium (RPMI).

Results: Results showed a considerable relaxivity increase for the Gd2O3–DEG particles compared to Gd-DTPA. Both T1 and T2 relaxivities in the presence of Gd2O3–DEG particles were approximately twice the corresponding values for Gd–DTPA in aqueous solution and even larger in RPMI. Higher signal intensity at low concentrations was predicted for the nanoparticle solutions, using experimental data to simulate a T1-weighted spin echo sequence.

Conclusion: The study indicates the possibility of obtaining at least doubled relaxivity compared to Gd–DTPA using Gd2O3–DEG nanocrystals as contrast agent. The high T1 relaxation rate at low concentrations of Gd2O3 nanoparticles is very promising for future studies of contrast agents based on gadolinium-containing nanocrystals.

Keywords

Gd2O3NanoparticleContrast agentRelaxivityMRI

Copyright information

© ESMRMB 2006