Magnetic Resonance Materials in Physics, Biology and Medicine

, Volume 16, Issue 5, pp 227–234

Automatic segmentation and plaque characterization in atherosclerotic carotid artery MR images


    • Division of Image Processing (LKEB)Department of Radiology
  • R. J. van der Geest
    • Division of Image Processing (LKEB)Department of Radiology
  • B. A. Wasserman
    • Department of RadiologyNeuroradiology Division
  • M. A. Mohamed
    • Department of RadiologyNeuroradiology Division
  • J. H. C. Reiber
    • Division of Image Processing (LKEB)Department of Radiology
  • B. P. F. Lelieveldt
    • Division of Image Processing (LKEB)Department of Radiology

DOI: 10.1007/s10334-003-0030-8

Cite this article as:
Adame, I., van der Geest, R., Wasserman, B. et al. Magn Reson Mater Phy (2004) 16: 227. doi:10.1007/s10334-003-0030-8


In vivo MRI provides a means to non-invasively image and assess the morphological features of atherosclerotic carotid arteries. To assess quantitatively the degree of vulnerability and the type of plaque, the contours of the lumen, outer boundary of the vessel wall and plaque components, need to be traced. Currently this is done manually, which is time-consuming and sensitive to inter- and intra-observer variability. The goal of this work was to develop an automated contour detection technique for tracing the lumen, outer boundary and plaque contours in carotid MR short-axis black-blood images. Seventeen patients with carotid atherosclerosis were imaged using high-resolution in vivo MRI, generating a total of 50 PD- and T1-weighted MR images. These images were automatically segmented using the algorithm presented in this work, which combines model-based segmentation and fuzzy clustering to detect the vessel wall, lumen and lipid core boundaries. The results demonstrate excellent correspondence between automatic and manual area measurements for lumen (r=0.92) and outer (r=0.91), and acceptable correspondence for fibrous cap thickness (r=0.71). Though further optimization is required, our algorithm is a powerful tool for automatic detection of lumen and outer boundaries, and characterization of plaque in atherosclerotic vessels.


Carotid artery MRIAtherosclerosisPlaque compositionMagnetic resonance imaging

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© ESMRMB 2004