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Drosophila Eyes Absent Homologue 2 is up-regulated in lung adenocarcinoma

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

Lung cancer has emerged as a leading cause of cancer death in the world. Eyes Absent (EYA) is an important and conserved transcriptional regulator of development. The aim of the present study was to identify the expression of Drosophila Eyes Absent Homologue 2 (EYA2) in non-small cell lung cancer (NSCLC) and to investigate their correlation with clinical parameters.

Methods

Fresh, paired lung samples (n = 59) of NSCLC were obtained by surgical resection at the Department of Thoracic Surgery of the People’s Liberation Army General Hospital. Expression of EYA2 were examined by Western blot and immunohistochemical analysis in specimens of NSCLC and paired normal lung tissue. Clinical data, pathologic result and Ki67 expression were collected and subsequent correlation with EYA2 expression was analyzed.

Results

EYA2 expression was found located in cytoplasm and nucleus, but mostly in cytoplasm. The expression of EYA2 increased in NSCLC by Western blot and immunohistochemistry, which was correlated with histology type, but not correlated with gender, age, pTNM stage, histological differentiation and lymph node metastasis. Compared with normal lung tissue, the expression of EYA2 significantly was up-regulated in lung adenocarcinoma, while no significant difference in lung squamous cell carcinoma. Expression of EYA2 was uncorrelated with expression of Ki67 in NSCLC.

Conclusion

Expression of EYA2 was augmented in lung adenocarcinoma. EYA2 is likely participating in tumorigenesis and development of lung adenocarcinoma as transcriptional activator.

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Authors and Affiliations

  1. Department of Thoracic Surgery, PLA General Hospital, Beijing, 100853, China

    Juntang Guo, Chaoyang Liang & Naikang Zhou

  2. Beijing Institute of Biotechnology, Beijing, 100850, China

    Lihua Ding & Qinong Ye

Authors
  1. Juntang Guo
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  2. Chaoyang Liang
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  3. Lihua Ding
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  4. Naikang Zhou
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  5. Qinong Ye
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Corresponding author

Correspondence to Juntang Guo.

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Guo, J., Liang, C., Ding, L. et al. Drosophila Eyes Absent Homologue 2 is up-regulated in lung adenocarcinoma. Chin. -Ger. J. Clin. Oncol. 8, 681–684 (2009). https://doi.org/10.1007/s10330-009-0166-8

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  • DOI: https://doi.org/10.1007/s10330-009-0166-8

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