, Volume 7, Issue 1, pp 22-26

The prediction of recurrence and survival of patients with Dukes’ B colorectal cancer after curative resection with immunohistochemical detection of Survivin and Livin expressions

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Abstract

Objective

To detect the expressions of Survivin and Livin in Dukes’ B colorectal cancer tissues and analyze the prognosis after curative resection.

Methods

The expressions of Survivin and Livin were evaluated immunohistochemically in Dukes’ B colorectal cancer specimens from 81 patients after curative resection of the tumor. Their correlations to clinical characters and survival were also explored.

Results

The positive rates of Survivin and Livin in colorectal cancer tissues were significantly higher than those in normal colorectal tissues (58.0% vs. 16.7% and 45.7% vs. 8.3% respectively, P < 0.05). The expressions of Survivin and Livin were not related to gender, tumor site, primary size, T stage, pathologic category, and degree of differentiation (P > 0.05), and no relationship was found between the expressions of Survivin and Livin (P > 0.05). The expression rate of Survivin in patients older than 50 years was higher than that in patients younger than 50 years (70.6% vs. 36.7%, P < 0.05). Both Survivin and Livin were related to recurrence and/or metastasis (P = 0.02 and P = 0.001, respectively), and shorter survival (P = 0.039 and P = 0.001, respectively). Cox multivariate analysis showed T4 and positive Livin expression were independent prognostic factors (P = 0.002 and P = 0.047, respectively).

Conclusion

Survivin and Livin are over-expressed in Dukes’ B colorectal cancer tissues and are positively related to recurrence and/or metastasis and poor prognosis after curative resection of the tumor.