Production of poly(3-hydroxybutyric-co-3-hydroxyvaleric acid) having a high hydroxyvalerate content with valeric acid feeding

Short Communication

DOI: 10.1007/s10295-007-0207-7

Cite this article as:
Khanna, S. & Srivastava, A.K. J Ind Microbiol Biotechnol (2007) 34: 457. doi:10.1007/s10295-007-0207-7


The capability of different organic acids to produce a derivative of PHB [poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), P(3HB-co-3HV)] was examined in shake flask cultivations. Propionic and valeric acids demonstrated the potential to produce P(3HB-co-3HV) under nitrogen limiting conditions at 30°C. The addition time and the initial concentration of valeric acid needed for a high cellular HV content were identified by extensive experimentation. Fed-batch cultivation in 7-l bioreactor with valeric acid feeding resulted in the production of PHA containing 54% HV units.


Valeric acid P(3HB-co-3HV) Propionic acid Wautersia eutropha PHB 

Copyright information

© Society for Industrial Microbiology 2007

Authors and Affiliations

  1. 1.Department of Biochemical Engineering and BiotechnologyIndian Institute of Technology, DelhiNew DelhiIndia