Journal of Industrial Microbiology and Biotechnology

, Volume 33, Issue 7, pp 523–531

Drug discovery from natural products

  • Vincent P. Gullo
  • James McAlpine
  • Kin S. Lam
  • Dwight Baker
  • Frank Petersen
Review Paper

DOI: 10.1007/s10295-006-0107-2

Cite this article as:
Gullo, V.P., McAlpine, J., Lam, K.S. et al. J IND MICROBIOL BIOTECHNOL (2006) 33: 523. doi:10.1007/s10295-006-0107-2


Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actinomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery of a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.


Drug discoveryNatural productsDrug targetsScreeningSecondary metabolism

Copyright information

© Society for Industrial Microbiology 2006

Authors and Affiliations

  • Vincent P. Gullo
    • 1
  • James McAlpine
    • 2
  • Kin S. Lam
    • 3
  • Dwight Baker
    • 4
  • Frank Petersen
    • 5
  1. 1.Cetek CorporationMarlboroughUSA
  2. 2.Ecopia BiosciencesSaint-LaurentCanada
  3. 3.Nereus Pharmaceuticals, Inc.San DiegoUSA
  4. 4.Cubist Pharmaceuticals, Inc.LexingtonUSA
  5. 5.Novartis Institutes for Biomedical ResearchBaselSwitzerland