Clinical Autonomic Research

, Volume 22, Issue 6, pp 303–306

Temporary elimination of orthostatic hypotension by norepinephrine infusion

  • David S. Goldstein
  • LaToya Sewell
  • Courtney Holmes
  • Sandra Pechnik
  • André Diedrich
  • David Robertson
Short Communication

DOI: 10.1007/s10286-012-0176-4

Cite this article as:
Goldstein, D.S., Sewell, L., Holmes, C. et al. Clin Auton Res (2012) 22: 303. doi:10.1007/s10286-012-0176-4

Abstract

A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a “prosthetic baroreceptor system” to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH.

Keywords

NorepinephrineOrthostatic hypotensionSympathetic nervous systemBaroreflex

Abbreviations

NE

Norepinephrine

OH

Orthostatic hypotension

Copyright information

© Springer-Verlag (outside the USA)  2012

Authors and Affiliations

  • David S. Goldstein
    • 1
  • LaToya Sewell
    • 1
  • Courtney Holmes
    • 1
  • Sandra Pechnik
    • 1
  • André Diedrich
    • 2
  • David Robertson
    • 3
  1. 1.Clinical Neurocardiology SectionNational Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  2. 2.Department of Biomedical EngineeringVanderbilt UniversityNashvilleUSA
  3. 3.Autonomic Dysfunction CenterVanderbilt University School of MedicineNashvilleUSA