Clinical Autonomic Research

, Volume 22, Issue 3, pp 117–122

A comprehensive study of autonomic dysfunction in the fibromyalgia patients

  • Poorvi Kulshreshtha
  • Rajiva Gupta
  • Raj Kumar Yadav
  • Ramesh Lal Bijlani
  • Kishore Kumar Deepak
Research Article

DOI: 10.1007/s10286-011-0150-6

Cite this article as:
Kulshreshtha, P., Gupta, R., Yadav, R.K. et al. Clin Auton Res (2012) 22: 117. doi:10.1007/s10286-011-0150-6

Abstract

Objectives

The hypothesis of autonomic nervous system involvement in pathophysiology in the patients with fibromyalgia has been addressed and tested time and again but the existing reports are both contradictory and inconclusive. A complete knowledge of the degree of autonomic dysfunction in fibromyalgia patients would be more substantial. We conducted a comprehensive non-invasive study to investigate the complete autonomic profile of female patients with fibromyalgia.

Method

An autonomic function test using a standard battery and heart rate variability analysis in the 42 fibromyalgia patients as well as 42 age matched healthy controls was performed. Both autonomic activity (tone) and reactivity were measured. Autonomic tone (both time and frequency domain parameters) was measured using heart rate variability (HRV) analysis. Autonomic reactivity was measured using a standard battery of autonomic function tests.

Results

Resting blood pressure (both systolic and diastolic) was significantly higher in the fibromyalgia patients than controls. The time domain variables and HF% as recorded by HRV were significantly lower in the patients than the controls. The autonomic reactivity for sympathetic and parasympathetic nervous system was found to be within normal limits.

Interpretation

The cardiac autonomic function is normal and the autonomic reflex arc seems to be intact in the patients with fibromyalgia.

Keywords

Fibromyalgia Autonomic nervous system Pain Heart rate variability 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Poorvi Kulshreshtha
    • 1
  • Rajiva Gupta
    • 2
  • Raj Kumar Yadav
    • 1
  • Ramesh Lal Bijlani
    • 1
  • Kishore Kumar Deepak
    • 1
  1. 1.Department of PhysiologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of MedicineAll India Institute of Medical SciencesNew DelhiIndia

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