Case Report

Clinical Autonomic Research

, Volume 21, Issue 1, pp 65-67

First online:

Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla

  • Koldo BerganzoAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU) Email author 
  • , Roberto CiordiaAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Juan C. Gómez-EstebanAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Beatriz TijeroAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Marta AgundezAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Fernando VelascoAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Maria A. ValleAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)
  • , Juan J. ZarranzAffiliated withDepartment of Neurology, Hospital CrucesDepartment of Neurosciences, University of the Basque Country (UPV/EHU)

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Abstract

Tako-tsubo-like cardiomyopathy (TTC) is much more common than originally thought. The exact pathophysiology of TTC is unclear. The most accepted theory proposes myocardial stunning of neurogenic origin, supported by the frequent antecedent of emotional or physical stress, suggesting a catecholamine-mediated mechanism. We present a patient with this syndrome and bilateral damage of the dorsal medulla oblongata likely affecting both solitary tract nuclei. Our case points to a link between baroreflex failure and TTC, highlighting the important role of sympathetic discharge in the pathophysiology of TTC.

Keywords

Tako-tsubo cardiomyopathy Solitary tract nucleus Baroreflex failure