Clinical Autonomic Research

, Volume 20, Issue 2, pp 93–99

Distal sudomotor findings in postural tachycardia syndrome

Authors

    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of NeurologyVanderbilt University School of Medicine
  • Emily Garland
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
  • Satish R. Raj
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
    • Department of PharmacologyVanderbilt University School of Medicine
  • Kyoko Sato
    • Department of Clinical PharmacologyTokai University School of Medicine
  • Bonnie Black
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
  • Yanna Song
    • Department of BiostatisticsVanderbilt University School of Medicine
  • Lily Wang
    • Department of BiostatisticsVanderbilt University School of Medicine
  • Italo Biaggioni
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
    • Department of PharmacologyVanderbilt University School of Medicine
  • Andre Diedrich
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
    • Department of Biomedical EngineeringVanderbilt University School of Medicine
  • David Robertson
    • Autonomic Dysfunction CenterVanderbilt University School of Medicine
    • Department of NeurologyVanderbilt University School of Medicine
    • Department of MedicineVanderbilt University School of Medicine
    • Department of PharmacologyVanderbilt University School of Medicine
Research Article

DOI: 10.1007/s10286-009-0045-y

Cite this article as:
Peltier, A.C., Garland, E., Raj, S.R. et al. Clin Auton Res (2010) 20: 93. doi:10.1007/s10286-009-0045-y

Abstract

Objectives

Postural tachycardia syndrome (POTS) is a heterogeneous disorder characterized by excessive orthostatic tachycardia in the absence of orthostatic hypotension and by sympathetic nervous system activation. Postganglionic sudomotor deficits have been used to define a neurogenic postural tachycardia POTS subtype. Norepinephrine levels above 600 pg/ml have also been used to delineate patients with a hyperadrenergic state. This study aims to determine the relationship of sudomotor abnormalities to other aspects of dysautonomia in POTS.

Methods

Autonomic function was quantified in thirty women through tests of cardiovagal, adrenergic, and sudomotor function including quantitative sudomotor axon reflex testing (QSART) and spectral indices. Differences between patients with and without sudomotor dysfunction as defined by QSART and between patients with and without hyperadrenergic POTS were assessed with Mann–Whitney U test and Mantel–Haenszel Chi-Square test using a p value of 0.01 for significance. Spearman correlation coefficients were used to test raw sweat volume correlations with other variables.

Results

Of 30 women (ages 20–58), 17 patients (56%) had an abnormal QSART which was typically patchy and involved the lower extremity, while 13 patients had normal QSART results. Other autonomic tests, catecholamines or spectral indices did not correlate with QSART results. No differences in autonomic tests or spectral indices were observed between hyperadrenergic and non-hyperadrenergic POTS.

Interpretation

Our findings confirm that a large subset of POTS patients have sudomotor abnormalities which are typically patchy in distribution but do not correlate with other tests of autonomic function. Further studies are needed to determine the best method of endophenotyping patients with POTS.

Keywords

Orthostatic intoleranceTachycardiaPOTSSudomotorAutonomic neuropathySweating

Copyright information

© Springer-Verlag 2009