Clinical Autonomic Research

, 19:13

Antibody testing as a diagnostic tool in autonomic disorders


    • Dept. of NeurologyUniversity of Texas, Southwestern Medical Center

DOI: 10.1007/s10286-008-0488-6

Cite this article as:
Vernino, S. Clin Auton Res (2009) 19: 13. doi:10.1007/s10286-008-0488-6


Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.


paraneoplastic autonomic ganglia

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© Steinkopff Verlag Darmstadt 2008