Clinical Autonomic Research

, Volume 17, Issue 6, pp 341–348

Exercise training improves cardiovascular and autonomic profiles in HIV

  • David K. Spierer
  • Ronald E. DeMeersman
  • Jay Kleinfeld
  • Eugene McPherson
  • Robert E. Fullilove
  • Augusta Alba
  • Adrienne S. Zion
RESEARCH ARTICLE

DOI: 10.1007/s10286-007-0441-0

Cite this article as:
Spierer, D.K., DeMeersman, R.E., Kleinfeld, J. et al. Clin Auton Res (2007) 17: 341. doi:10.1007/s10286-007-0441-0

Abstract

Objectives

Human immunodeficiency virus (HIV) is associated with cardiovascular (CV) and autonomic dysfunction, however the effects of fitness on vascular and autonomic mechanisms in HIV disease are unknown.

Methods

We studied forty-eight subjects (40.4 ± 4.2 years) in a cross-sectional design matched for age, gender, BMI, and fitness. Participants were assigned to 1 in 4 groups: 1) Healthy Unfit (HU), 2) Healthy Fit (HF), 3) HIV Positive Unfit (HPU), and 4) HIV Positive Fit (HPF). Fitness was assessed via open-circuit spirometry; arterial compliance and autonomic modulations were measured via applanation tonometry and power spectral analysis, respectively, and baroreflex sensitivity was obtained using the alpha index.

Results

Arterial compliance was augmented in HPF vs. HPU [7.4 ± 1.9 mmHg × second vs. 4.4 ± 1.7 mmHg × second (P = 0.006)]. Parasympathetic modulation was higher in HPF vs. HPU [2244.5 ± 2997.6 msecond2 vs. 489.1 ± 552.9 msecond2 (P < 0.05)]. Sympathetic modulation was lower in HPF vs. HU [4.7 ± 5.0 mmHg2 vs. 12.9 ± 9.7 mmHg2 (P < 0.05)]. Baroreflex sensitivity was higher in HPF vs. HPU [17.3 ± 10.2 msecond/mmHg vs. 7.4 ± 3.8 msecond/mmHg (P = 0.003)], and HPF vs. HU [17.3 ± 10.2 msecond/mmHg vs. 6.2 ± 3.0 msecond/mmHg (P = 0.004)].

Conclusions

Augmentations in arterial compliance and baroreflex sensitivity associated with fitness portent an improved CV and autonomic profile for HIV-positive individuals. Physical activity may be an adjuvant method to enhance the overall vascular health in HIV-compromised individuals.

Key words

immunodeficiencyHIVexercisefitnessbaroreflexautonomic nervous system

Copyright information

© Springer 2007

Authors and Affiliations

  • David K. Spierer
    • 1
    • 2
  • Ronald E. DeMeersman
    • 3
  • Jay Kleinfeld
    • 1
  • Eugene McPherson
    • 1
  • Robert E. Fullilove
    • 4
  • Augusta Alba
    • 1
  • Adrienne S. Zion
    • 5
  1. 1.Coler Goldwater Specialty Hospital and Nursing FacilityRoosevelt IslandUSA
  2. 2.Division of Sports Sciences, School of Health ProfessionsLong Island University, Brooklyn CampusBrooklynUSA
  3. 3.Dept. of Rehabilitation MedicineCollege of Physicians & SurgeonsNew YorkUSA
  4. 4.Mailman School of Public HealthColumbia UniversityNew YorkUSA
  5. 5.Teachers CollegeColumbia UniversityNew YorkUSA