Date: 29 Nov 2007
Exercise training improves cardiovascular and autonomic profiles in HIV
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Human immunodeficiency virus (HIV) is associated with cardiovascular (CV) and autonomic dysfunction, however the effects of fitness on vascular and autonomic mechanisms in HIV disease are unknown.
We studied forty-eight subjects (40.4 ± 4.2 years) in a cross-sectional design matched for age, gender, BMI, and fitness. Participants were assigned to 1 in 4 groups: 1) Healthy Unfit (HU), 2) Healthy Fit (HF), 3) HIV Positive Unfit (HPU), and 4) HIV Positive Fit (HPF). Fitness was assessed via open-circuit spirometry; arterial compliance and autonomic modulations were measured via applanation tonometry and power spectral analysis, respectively, and baroreflex sensitivity was obtained using the alpha index.
Arterial compliance was augmented in HPF vs. HPU [7.4 ± 1.9 mmHg × second vs. 4.4 ± 1.7 mmHg × second (P = 0.006)]. Parasympathetic modulation was higher in HPF vs. HPU [2244.5 ± 2997.6 msecond2 vs. 489.1 ± 552.9 msecond2 (P < 0.05)]. Sympathetic modulation was lower in HPF vs. HU [4.7 ± 5.0 mmHg2 vs. 12.9 ± 9.7 mmHg2 (P < 0.05)]. Baroreflex sensitivity was higher in HPF vs. HPU [17.3 ± 10.2 msecond/mmHg vs. 7.4 ± 3.8 msecond/mmHg (P = 0.003)], and HPF vs. HU [17.3 ± 10.2 msecond/mmHg vs. 6.2 ± 3.0 msecond/mmHg (P = 0.004)].
Augmentations in arterial compliance and baroreflex sensitivity associated with fitness portent an improved CV and autonomic profile for HIV-positive individuals. Physical activity may be an adjuvant method to enhance the overall vascular health in HIV-compromised individuals.
Avolio A, Chen S, Wang R, Zhang C, Li M, O’Rourke M, et al. (1983) Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68:50–58.PubMed
Bigger J, Fleiss J, Steinman R, Rolintzky L, Kleiger R, Rottman JN, et al. (1992) Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 85:164–171.PubMed
Billman GE, Schwartz PJ, Stone HL (1982) Barroreceptor control of heart rate: a predictor of sudden cardiac death. Circulation 66:874–879.PubMed
Billman G, Schwartz P, Stone L, et al. (1984) The effects of daily exercise on susceptibility to sudden cardiac death. Ciculation 69:1182–1189.
Bloomfield P (1976) Fourier analysis of time series: an introduction. John Wiley Publishing, New York.
Cerati D, Schwartz PJ (1991) Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death. Circ Res 69:1389–1401.PubMed
Cheminot N, Gariepy J, Chironi G, et al. (2000) Diagnosis and determinants of sub-clinical arterial disease in HIV-1 infected patients on HAART. In: 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA.
Cohen J, Laudenslager M (1989) Autonomic nervous system involvement in patients with HIV infection. Neurology 39:1111–1112.PubMed
Cohn J, Finkelstein S, McVeigh G, Morgan D, Le May L, et al. (1995) Noninvasive pulse wave analysis for the early detection of vascular disease. Hypertension 26:503–508.PubMed
Davey K, Miniciler N, Taylor A, et al. (1996) Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect? Am J Physiol 271:H455–H460.
De Castro S, et al. (1992) Heart involvement in AIDS: a prospective study during various stages of the disease. Eur Heart J 11:1452–1459.
DeMeersman R (1989) New noninvasive computerized method for the area measurement of the dicrotic notch. Comp Biol Med 9:189–195.CrossRef
DeMeersman R (1992) Respiratory sinus arrhythmia alteration following training in endurance athletes. Eur J Appl Physiol 64:434–436.CrossRef
DeMeersman R (1993) Heart rate variability and aerobic fitness. Am Heart J 125:726–731.CrossRef
De Souza C, Shapiro L, Clevenger C, et al. (2000) Regular aerobic exercise prevents/restores the age related decline in endothelium-dependent vasodilation in healthy men. Circulation 102:1351–1357.
Dixon E, Kamath M, McCartney N, et al. (1992) Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardiovasc Res 26:713–719.PubMed
Farrell T, Paul V, Crippe T, Malik M, et al. (1991) Baroreflex sensitivity and electrophysiological correlates in patients after acute myocardial infarction. Circulation 83:945–952.PubMed
Freeman R (1997) Autonomic failure and AIDS. In: Low PA (ed) Clinical autonomic disorders, 2nd edn. Lippincott-Raven, Philadelphia, pp 727–735.
Freeman R, Roberts M, Friedman L, Broadbridge C, et al. (1990) Autonomic function and human immunodeficiency virus infection. Neurology 40(4):575–580.PubMed
Gibbons RJ, Balady GJ, Beasley JW, Bricker JT, Duvernoy WF, Froelicher VF, et al. (1997) ACC/AHA guidelines for exercise testing. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). J Am Coll Cardiol 30(1):260–311.PubMedCrossRef
Goldsmith R, Bigger J, Bloomfield D, Steinmann R, et al. (1997) Physical fitness as a determinant of vagal modualtion. Med Sci Sports Exerc 29(6):812–817.PubMed
Hoffman C, Jaeger H (2001) Cardiology and AIDS: HAART and the consequences Ann NY Acad Sci 946:130–144.CrossRef
Johnson J, Anders G, Blanton H, et al. (1990) Exercise dysfunction in patients seropositive for the human immunodeficiency virus-1. Am Rev Respir Dis 141:618–622.PubMed
La Rovere MT, Bigger JT, Marcus Fl, Mortara A, Schwartz PJ, et al. (1998) Baroreflex sensitivity and heart period variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 14:478–484.CrossRef
Lenormand-Welckenaer C, Cazaubon M, Joly V, et al. (2000) Carotid intima media thickness in protease inhibitors-treated HIV-1 infected patients with hyperlipidemia. In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario.
Milei J, Grana D, Alonso GF, Matturi L, et al. (1998) Cardiac involvement in the acquired immune deficiency syndrome—a review to push action. Committee for the Study of Cardiac Involvement in AIDS. Clin Cardiol 21:465–472.PubMed
Nichols WW, O’Rourke MF (1998) McDonald’s blood flow in arteries, 4th edn. Arnold, London.
Raab W, Silva PP, Machet H, Kimura E, YK S (1960) Cardiac adrenergic preponderence due to lack of physical exercise and its pathogenic complications Am J Cardiol 5:300–320.
Rogstad KE, Shah R, Tesfaladet G, Abdullah M, Ahmed-Jushuf I, et al. (1999) Cardiovascular autonomic neuropathy in HIV infected patients. Sex Transm Infect 75(4):264–267.PubMed
Seals DR (2003) Habitual exercise and the age-associated decline in larger artery compliance. Med Sci Sports Exerc 31(2):68–72.
Shi X, Walter DW, Formes KJ, et al. (2000) Orthostatic hypotension in aging humans. Am J Physiol 279:H1548–H1554.
Stringer WW, Berezovskaya M, O’brien WA, Beck CK, Casburi R, et al. (1998) The effect of exercise training on aerobic fitness, immune idices, and quality of life in HIV+ patients. Med Sci Sports Exerc 30:11–16.PubMed
TaskForce of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use Circulation 93(5):1043–1065.
The different stages of HIV infection. Avert 2002 June 26.
Thomas D, Zimmerman S, Hansen T, et al. (2000) Collagen gene expression in rat left ventricle: interactive effect of age and exercise training. J Appl Physiol 89:1462–1468.PubMed
Villa A, Foresti V, Confalonieri F (1987) Autonomic neuropathy and HIV infection. Lancet 1:915.CrossRef
Watt TB, Burrus C (1976) Arterial pressure contour analysis for estimating human vascular properties. J Appl Physiol 40:171–176.PubMed
- Exercise training improves cardiovascular and autonomic profiles in HIV
Clinical Autonomic Research
Volume 17, Issue 6 , pp 341-348
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- autonomic nervous system
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- 1. Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA
- 2. Division of Sports Sciences, School of Health Professions, Long Island University, Brooklyn Campus, Room HS 303, 1 University Plaza, Brooklyn, NY, 11201, USA
- 3. Dept. of Rehabilitation Medicine, College of Physicians & Surgeons, New York, NY, USA
- 4. Mailman School of Public Health, Columbia University, New York, NY, USA
- 5. Teachers College, Columbia University, New York, NY, USA