Clinical Autonomic Research

, Volume 17, Issue 2, pp 118–121

Cardiac sympathetic denervation preceding motor signs in Parkinson disease

  • David S. Goldstein
  • Yehonatan Sharabi
  • Barbara I. Karp
  • Oladi Bentho
  • Ahmed Saleem
  • Karel Pacak
  • Graeme Eisenhofer
CASE REPORT

DOI: 10.1007/s10286-007-0396-1

Cite this article as:
Goldstein, D.S., Sharabi, Y., Karp, B.I. et al. Clin Auton Res (2007) 17: 118. doi:10.1007/s10286-007-0396-1

Abstract

There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.

Keywords

Parkinson disease sympathetic nervous system baroreflex heart imaging techniques autonomic nervous system 

Copyright information

© Steinkopff Verlag Darmstadt 2007

Authors and Affiliations

  • David S. Goldstein
    • 1
  • Yehonatan Sharabi
    • 1
  • Barbara I. Karp
    • 2
  • Oladi Bentho
    • 1
  • Ahmed Saleem
    • 1
  • Karel Pacak
    • 3
  • Graeme Eisenhofer
    • 1
  1. 1.Clinical Neurocardiology SectionNINDS, NIHBethesdaUSA
  2. 2.Clinical Neurosciences ProgramNational Institute of Neurological Disorders and StrokeBethesdaUSA
  3. 3.Reproductive Biology and Medicine BranchNational Institute of Child Health and Development, NIHBethesdaUSA

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